Tavassoli M
Br J Haematol. 1977 Jan;35(1):25-32. doi: 10.1111/j.1365-2141.1977.tb00559.x.
The extent of marrow sinus wall coverage by perisinal adventitial cells was measured before and after removing 25% of the calculated blood volume in rabbits. A marked reduction in the area covered by adventitial cells was recorded coinciding with the early reticulocyte response to phlebotomy. In control animals, only scattered microfilaments were occasionally observed in the cytoplasmic process of adventitial cells. After phlebotomy, these filaments were more frequently observed and appeared as band-like structures, raising the possibility of an active role for perisinal adventitial cells in response to fluctuations in the magnitude of cell traffic. Perisinal adventitial cells may, therefore, translate the body's demand for cell delivery by regulating the rate of transmural cell migration from the marrow. Such an adaptive mechanism may depend on the incompleteness of the adventitial layer of the sinus wall and the absence of endothelial-adventitial cell junctions, permitting separation of the two layers of the wall, so that the reticulocyte can gain access to more endothelial surface and the pores.
在去除家兔25%的计算血容量前后，测量了窦周外膜细胞覆盖骨髓窦壁的范围。记录到外膜细胞覆盖面积显著减少，这与早期网织红细胞对放血的反应一致。在对照动物中，在外膜细胞的细胞质突起中偶尔仅观察到散在的微丝。放血后，这些微丝更频繁地被观察到，并呈现为带状结构，这增加了窦周外膜细胞在应对细胞流量大小波动时发挥积极作用的可能性。因此，窦周外膜细胞可能通过调节骨髓跨壁细胞迁移速率来转化机体对细胞输送的需求。这种适应性机制可能取决于窦壁外膜层的不完整性以及内皮-外膜细胞连接的缺失，从而允许壁的两层分离，以便网织红细胞能够接触到更多的内皮表面和孔隙。
