6-硫鸟嘌呤：腺嘌呤可在体外阻止其对人淋巴细胞的抗有丝分裂作用。
6-thioguanine: antimitotic effect on human lymphocytes in vitro prevented by adenine.
作者信息
Price D J, Timson J
出版信息
Br J Cancer. 1971 Mar;25(1):106-8. doi: 10.1038/bjc.1971.15.
Abstract
The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase.
摘要
已对6-硫鸟嘌呤在体外对PHA刺激的人淋巴细胞分裂的作用进行了研究，结果表明它具有明确的抗有丝分裂作用，这种作用可被腺嘌呤阻止，但不能被鸟嘌呤或次黄嘌呤阻止。有人提出，在这个测试系统中，6-TG对磷酸核糖焦磷酸酰胺转移酶发挥其主要抑制作用。
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