通过用细菌合成的非结构蛋白（NS1）片段免疫来降低黄热病毒对小鼠的神经毒力。
Reduction of yellow fever virus mouse neurovirulence by immunization with a bacterially synthesized non-structural protein (NS1) fragment.
作者信息
Cane P A, Gould E A
机构信息
London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, St Albans, Hertfordshire, U.K.
出版信息
J Gen Virol. 1988 Jun;69 ( Pt 6):1241-6. doi: 10.1099/0022-1317-69-6-1241.
PMID:3133449
Abstract
Part of a yellow fever virus-specified non-structural protein (NS1) was expressed in Escherichia coli as a fusion protein with beta-galactosidase. Immunization of mice with this partially purified NS1-beta-galactosidase fusion protein induced yellow fever virus-specific antibodies and provided some protection against intracerebral challenge with the virus.
摘要
黄热病病毒特定的一种非结构蛋白（NS1）的一部分在大肠杆菌中作为与β-半乳糖苷酶的融合蛋白表达。用这种部分纯化的NS1-β-半乳糖苷酶融合蛋白免疫小鼠可诱导产生黄热病病毒特异性抗体，并提供一定程度的针对该病毒脑内攻击的保护作用。
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