与贻贝相关的甲型病毒性肝炎：血清学确诊

Mussel-associated viral hepatitis, type A: serological confirmation.

作者信息

Dienstag J L, Gust I D, Lucas C R, Wong D C, Purcell R H

出版信息

Lancet. 1976 Mar 13;1(7959):561-3. doi: 10.1016/s0140-6736(76)90358-5.

Abstract

7 members of a family of 14 developed acute viral hepatitis approximately one month after a family outing. Epidemiological investigation incriminated incompletely cooked mussels (Mytilus edulis) as the vehicle of infection and revealed a statistically significant difference in attack-rates between mussel-ingesters (70%) and non-ingesters (0%) (P=0-035). The aetiological role of hepatitis-A virus, suspected on epidemiological grounds, was serologically confirmed by the demonstration of rises in titres of serum-antibody to hepatitis-A antigen (serologically related to the MS-1 strain of hepatitis-A virus), determined by immune adherence haemagglutination.

摘要

一个14口之家的7名成员在一次家庭郊游约一个月后患上了急性病毒性肝炎。流行病学调查认定未熟透的贻贝（紫贻贝）为感染媒介，并显示食用贻贝者（70%）和未食用者（0%）的发病率存在统计学上的显著差异（P = 0.035）。基于流行病学依据怀疑的甲型肝炎病毒的病因学作用，通过免疫粘连血凝试验测定血清中抗甲型肝炎抗原抗体（与甲型肝炎病毒MS - 1株血清学相关）滴度升高得到血清学证实。