二甲基亚硝胺抑制蛋白质合成的一种可能机制。
A possible mechanism of inhibition of protein synthesis by dimethylnitrosamine.
作者信息
Villa-Treviño S
出版信息
Biochem J. 1967 Nov;105(2):625-31. doi: 10.1042/bj1050625.
Abstract
- The incorporation of [(14)C]leucine into liver proteins of rats was measured in vivo at various times after treatment of the animals with dimethylnitrosamine and was correlated with the state of the liver ribosomal aggregates. Inhibition of incorporation ran parallel with breakdown of the aggregates. 2. Inhibition of leucine incorporation into protein and breakdown of ribosomal aggregates were not preceded by inhibition of incorporation of [(14)C]orotate into nuclear RNA of the liver. 3. Evidence was obtained of methylation of nuclear RNA in the livers of rats treated with [(14)C]dimethylnitrosamine. 4. Zonal centrifugation analysis of radioactive, nuclear, ribosomal and transfer RNA from livers of rats treated with [(14)C]dimethylnitrosamine revealed labelling of all centrifugal fractions to about the same extent. 5. It is suggested that methylation of messenger RNA might occur in the livers of dimethylnitrosamine-treated rats and the possible relation of this to inhibition of hepatic protein synthesis is discussed.
摘要
- 在用二甲基亚硝胺处理动物后的不同时间，在体内测量了[(14)C]亮氨酸掺入大鼠肝脏蛋白质的情况，并将其与肝脏核糖体聚集体的状态相关联。掺入的抑制与聚集体的分解平行。2. 亮氨酸掺入蛋白质的抑制和核糖体聚集体的分解之前，[(14)C]乳清酸掺入肝脏核RNA并未受到抑制。3. 在用[(14)C]二甲基亚硝胺处理的大鼠肝脏中，获得了核RNA甲基化的证据。4. 对用[(14)C]二甲基亚硝胺处理的大鼠肝脏中的放射性、核、核糖体和转移RNA进行区带离心分析，发现所有离心级分的标记程度大致相同。5. 有人提出，在二甲基亚硝胺处理的大鼠肝脏中可能发生信使RNA的甲基化，并讨论了其与肝蛋白质合成抑制的可能关系。
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