Schechter M D
Pharmacol Biochem Behav. 1977 Mar;6(3):359-61. doi: 10.1016/0091-3057(77)90038-7.
Neither 0.05 mg/kg d-amphetamine nor 15 mg/kg caffeine alone produce amphetamine-like responding in rats trained in two-lever operant chambers to discriminate 0.8 mg/kg d-amphetamine from saline. The co-administration of the two drug doses produced responding similar to the 0.8 mg/kg d-amphetamine dose. A suggestion for the mechanism of action and a regimen of administration for caffeine in hyperkinetic children are discussed.
在双杠杆操作箱中接受训练以区分0.8mg/kg右旋苯丙胺和生理盐水的大鼠，单独给予0.05mg/kg右旋苯丙胺或15mg/kg咖啡因均不会产生类似苯丙胺的反应。两种药物剂量共同给药产生的反应类似于0.8mg/kg右旋苯丙胺剂量。文中讨论了对多动儿童咖啡因作用机制的一种推测以及给药方案。
