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塞浦路斯的Q热与动物流产

Q fever and animal abortion in Cyprus.

作者信息

Spicer A J, Crowther R W, Vella E E, Bengtsson E, Miles R, Pitzolis G

出版信息

Trans R Soc Trop Med Hyg. 1977;71(1):16-20. doi: 10.1016/0035-9203(77)90198-5.

DOI:10.1016/0035-9203(77)90198-5
PMID:558666
Abstract

Seventy-eight British soldiers stationed in the Eastern Sovereign Base Area (ESBA) in Cyprus contracted Q fever in the period December 1974 to June 1975. Pneumonia developed in 59% of cases. Of 31 patients tested, 81% had biochemical evidence of hepatitis although only one became clinically jaundiced. Three patients (4%) suffered pericarditis. Treatment with tetracycline had no apparent effect on the course of the disease. Investigation revealed an abortion epidemic involving 21 mixed flocks of sheep and goats in the south-eastern coastal region. 11 of the flocks grazed in and around the ESBA. A serological survey of 10 affected flocks, and evidence collected from previous years, indicated that the abortion epidemic was the result of infection with Coxiella burneti. Infection in the humans was almost certainly acquired by inhalation of dust from brush contaminated with rickettsial parturition products of the aborting flocks. A human serological survey revealed a number of cases of subclinical Q fever in a susceptivle military population, and an asymptomatic epidemic in a largely immune local position.

摘要

1974年12月至1975年6月期间,78名驻扎在塞浦路斯东部主权基地区(ESBA)的英国士兵感染了Q热。59%的病例出现了肺炎。在接受检测的31名患者中,81%有肝炎的生化证据,尽管只有1人出现临床黄疸。3名患者(4%)患了心包炎。四环素治疗对病程没有明显影响。调查发现东南部沿海地区有21群绵羊和山羊发生了流产疫情。其中11群在ESBA及其周边地区放牧。对10个受影响畜群的血清学调查以及从往年收集的证据表明,流产疫情是由伯氏考克斯体感染所致。人类感染几乎可以肯定是通过吸入被流产畜群的立克次体分娩产物污染的灌木丛中的灰尘而获得的。一项人类血清学调查显示,在易感军人人群中有多例亚临床Q热病例,在基本具有免疫力的当地人群中有无症状疫情。

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