高压氧对二度烧伤创面愈合的影响。

Effect of hyperbaric oxygen on second-degree burn wound healing.

作者信息

Korn H N, Wheeler E S, Miller T A

出版信息

Arch Surg. 1977 Jun;112(6):732-7. doi: 10.1001/archsurg.1977.01370060064011.

DOI:10.1001/archsurg.1977.01370060064011

Abstract

We present a controlled study that indicates faster epithelialization of blister-removed second-degree burn wounds in guinea pigs treated with hyperbaric oxygen (HBO). Assessment of vascularity by india ink perfusion indicated earlier return of capillary patency in the HBO-treated group. An examination of the question of a comparative increase in DNA synthetic activity in the HBO-treated animals showed a slightly higher absolute ratio of labeled to unlabeled cells, but the difference was not statistically significant. It is likely that the mechanisms whereby HBO influenced the above events were mediated not only by increased oxygen delivery, but by increased atmospheric pressure on the wound.

摘要

我们进行了一项对照研究，结果表明，接受高压氧（HBO）治疗的豚鼠去除水疱的二度烧伤创面上皮化速度更快。通过印度墨水灌注评估血管生成情况，结果显示HBO治疗组的毛细血管通畅恢复得更早。对HBO治疗动物中DNA合成活性相对增加问题的检查表明，标记细胞与未标记细胞的绝对比例略高，但差异无统计学意义。HBO影响上述事件的机制可能不仅是通过增加氧气输送，还通过增加伤口处的大气压来介导的。