Robertson M R, Potter E V, Roberts M L, Patterson R
Nephron. 1976;16(4):256-71. doi: 10.1159/000180610.
Samples of renal tissue from 373 patients were examined for the presence of immunoglobulin E (IgE) by immunofluorescent techniques. Only trace to ++ amounts ( on a scale of ++++) were found in 20 patients: 4/9 with post-streptococcal acute glomerulonephritis (GN), 5/30 with GN associated with systemic lupus erythematosus, 3/20 with membranous GN, 1/4 with Goodpasture's syndrome, 2/18 with recurrent microhematuria and focal GN, 1/5 with hemolytic anemia and uremia, 3/73 with renal homografts, and 1/5 with dermatomyositis. No IgE was found in 18 patients with lipoid nephrosis, 8 of whom were being treated with prednisone, nor in 5 patients with focal glomerular sclerosis and the nephrotic syndrome. Serum IgE was measured in 9 of the 20 patients with glomerular deposits of this globulin. With one exception, levels of IgE were within the range generally considered to be normal. However, they were greater than the mean of this range in all but two and near the highest limits of normal in most. Neither the amounts of serum IgE nor the degree of proteinuria could be related to the intensity of stain for IgE in the glomeruli of these patients.
采用免疫荧光技术检测了373例患者的肾组织样本中免疫球蛋白E（IgE）的存在情况。仅在20例患者中发现微量至++（++++分级）：9例链球菌感染后急性肾小球肾炎（GN）患者中有4例，30例与系统性红斑狼疮相关的GN患者中有5例，20例膜性GN患者中有3例，4例Goodpasture综合征患者中有1例，18例复发性镜下血尿和局灶性GN患者中有2例，5例溶血性贫血和尿毒症患者中有1例，73例肾移植患者中有3例，5例皮肌炎患者中有1例。18例脂性肾病患者中未发现IgE，其中8例正在接受泼尼松治疗，5例局灶性肾小球硬化和肾病综合征患者中也未发现IgE。在20例有这种球蛋白肾小球沉积物的患者中，对9例患者检测了血清IgE。除1例外，IgE水平均在通常认为正常的范围内。然而，除2例外，所有患者的IgE水平均高于该范围的平均值，且大多数患者接近正常范围的上限。这些患者肾小球中IgE的染色强度与血清IgE量及蛋白尿程度均无关联。
