Persson L, Rosengren L
Acta Neurol Scand. 1977 Jul;56(1):7-16. doi: 10.1111/j.1600-0404.1977.tb01404.x.
Control and ethanol-intoxicated rats were injured with a small cerebral stab wound and the extravasation of Evans blue-labelled albumin (EBA) was studied. Control rats displayed an extravasation of EBA in the immediate peri-traumatic area with subsequent uptake of EBA in neurons and glia. Ethanol-intoxicated rats showed a greater leakage of EBA as well as a wider area of leaking blood vessels around the stab wound, both in the peri-traumatic and in the early post-traumatic period. Neuronal uptake of EBA was enhanced and observed in a wider area in intoxicated than control rats. The difference in distribution of EBA among neurons and glia between intoxicated and control rats was partly a consequence of the difference in leakage of EBA in the experimental groups. However, part of the increased neuronal uptake of EBA might be explained by an effect of ethanol on nueronal plasmalemma. The results obtained indicated a more pronounced injury to endothelial and neuronal cells after small cerebral stab wounds in ethanol-intoxicated compared to control rats.
对对照组大鼠和乙醇中毒大鼠造成轻微脑刺伤，并研究伊文思蓝标记白蛋白（EBA）的外渗情况。对照组大鼠在创伤周围立即出现EBA外渗，随后神经元和胶质细胞摄取EBA。乙醇中毒大鼠在创伤周围和创伤后早期，EBA渗漏均更严重，刺伤伤口周围血管渗漏区域也更广泛。与对照组大鼠相比，中毒大鼠EBA的神经元摄取增强，且摄取区域更广泛。中毒大鼠和对照组大鼠之间，EBA在神经元和胶质细胞中的分布差异，部分是由于实验组中EBA渗漏的差异所致。然而，EBA神经元摄取增加的部分原因，可能是乙醇对神经细胞质膜的作用。所得结果表明，与对照组大鼠相比，乙醇中毒大鼠在轻微脑刺伤后，内皮细胞和神经元细胞损伤更明显。
