Briggs M H
Aust Fam Physician. 1977 Mar;Suppl:12-5.
Metabolic activation of mestranol and certain progestagens is necessary before combination with their specific receptors. This process is subject to inhibition by other drugs. It is suggested that it is preferable to use agents not requiring metabolic activation. Widespread variation of human metabolic parameters is induced by oral contraceptives. A dose related effect of synthetic oestrogens on the synthesis and release of liver-derived plasma proteins is a major cause of this variation. The changes induced may be modified by norgestrel but not by other available progestagens. Changes in various specific plasma proteins, carrier proteins, enzymes and coagulation factors are discussed.
炔雌醇甲醚和某些孕激素在与它们的特定受体结合之前需要进行代谢激活。这个过程会受到其他药物的抑制。建议最好使用不需要代谢激活的药物。口服避孕药会引起人体代谢参数的广泛变化。合成雌激素对肝脏来源的血浆蛋白合成和释放的剂量相关效应是这种变化的主要原因。所引起的变化可能会被炔诺孕酮改变，但不会被其他可用的孕激素改变。文中讨论了各种特定血浆蛋白、载体蛋白、酶和凝血因子的变化。
