Briggs M H
Aust Fam Physician. 1977 Mar;Suppl:23-8.
Biochemical studies on large groups of apparently healthy women taking oral contraceptives are intended to find which organs and tissues are most stressed, in the hope than an indication of clinical side effects will result. If contraceptive steroid dose is reduced, the incidence of systemic side effects decreases and this correlates well with the decreased abnormality of many metabolic and biochemical parameters. Reduction of dosage has an equivocal effect on gynaecological side affects-some increase, some decrease. An account is given of the possible relationship between clinical side effects of oral contraceptives, and dose-related changes in plasma proteins, vitamin status and tissue enzymes.
对大量服用口服避孕药的表面健康女性进行生化研究，旨在找出哪些器官和组织承受的压力最大，以期能由此发现临床副作用的迹象。如果降低避孕甾体激素剂量，全身副作用的发生率就会降低，这与许多代谢和生化参数异常情况的减少密切相关。剂量降低对妇科副作用的影响并不明确——有些副作用会增加，有些则会减少。本文阐述了口服避孕药的临床副作用与血浆蛋白、维生素状态及组织酶的剂量相关变化之间可能存在的关系。
