Briggs M H, Briggs M
N Z Med J. 1976 Apr 28;83(562):257-61.
Recent developments in knowledge of sex hormone receptors and steroid analogue metabolism allow a rational selection of oral contraceptive steroids from among the numerous available products. Dose related metabolic effects of synthetic estrogens have been demonstrated. Many of these estrogenic actions are antagonised by norgestrel but not by any other commercially available progestogen. Generalised activation of lysosomal enzymes can be demonstrated in oral contraceptive users and is shown to be related to the total steroid dose per cycle, rather than to particular products. These findings suggest that the lowest dose combination of ethynylestradiol and d-norgestrel is the product of choice. Clinical results with such a product are described.
性激素受体和类固醇类似物代谢知识的最新进展，使得能够从众多现有产品中合理选择口服避孕药类固醇。已证实合成雌激素存在剂量相关的代谢效应。这些雌激素作用中的许多都被炔诺孕酮拮抗，但不被任何其他市售孕激素拮抗。口服避孕药使用者体内可证实溶酶体酶的普遍激活，且已表明这与每个周期的总类固醇剂量有关，而非与特定产品有关。这些发现表明，乙炔雌二醇和d-炔诺孕酮的最低剂量组合是首选产品。本文描述了使用该产品的临床结果。
