Drew J H, Parkinson P, Walstab J E, Beischer N A
Med J Aust. 1977 Jun 25;1(26):945-9. doi: 10.5694/j.1326-5377.1977.tb131273.x.
The incidence of fetal malformations in a teaching hospital was determined by prospective study of 10,454 consecutively born infants. One or more major malformation was detected in 424 (4-1%) and one or more minor malformation was detected in 680 (6-5%). Major malformations were more common in stillborn infants (14-1%), in those who died in the neonatal period (36-7%) and in those who were small for dates (8-6%). Small for dates infants were the only group with a significant increase in the incidence of minor malformations (9-7%). The most common major malformations involved the genital organs (17-8%), limbs (14-2%), heart (11-4%) and central nervous system (10-6%). The most common minor malformations involved the skin, hair and nails (67-3%), limbs (7-7%) and genital organs (5-5%). Small for dates infants should be carefully examined to exclude major and minor malformations.
通过对一家教学医院连续出生的10454名婴儿进行前瞻性研究，确定了胎儿畸形的发生率。在424名（4.1%）婴儿中检测到一种或多种严重畸形，在680名（6.5%）婴儿中检测到一种或多种轻微畸形。严重畸形在死产婴儿中更为常见（14.1%），在新生儿期死亡的婴儿中（36.7%）以及小于孕周的婴儿中（8.6%）更为常见。小于孕周的婴儿是唯一轻微畸形发生率显著增加的组（9.7%）。最常见的严重畸形涉及生殖器官（17.8%）、四肢（14.2%）、心脏（11.4%）和中枢神经系统（10.6%）。最常见的轻微畸形涉及皮肤、毛发和指甲（67.3%）、四肢（7.7%）和生殖器官（5.5%）。应仔细检查小于孕周的婴儿，以排除严重和轻微畸形。
