Dickinson D B, Misch M J, Drury R E
Science. 1967 Jun 30;156(3783):1738-9. doi: 10.1126/science.156.3783.1738.
Dimethyl sulfoxide prevented loss of respiratory control and decrease in efficiency of oxidative phosphorylation when plant mitochondria were stored in liquid nitrogen. Respiration was severely inhibited and was not stimulated by adenosine diphosphate when mitochondria were frozen in liquid nitrogen without dimethyl sulfoxide. Thus, isolated mitochondria provide a model system for the study of the effects of freezing on biological membranes and of the prevention, by dimethyl sulfoxide, of freezing damage.
当植物线粒体保存在液氮中时，二甲基亚砜可防止呼吸控制的丧失和氧化磷酸化效率的降低。当线粒体在没有二甲基亚砜的情况下于液氮中冷冻时，呼吸会受到严重抑制，且不受二磷酸腺苷的刺激。因此，分离的线粒体为研究冷冻对生物膜的影响以及二甲基亚砜对冷冻损伤的预防作用提供了一个模型系统。
