免疫反应的遗传控制。无反应小鼠免疫（IgG）记忆中的选择性缺陷。
Genetic control of the immune response. A selective defect in immunologic (IgG) memory in nonresponder mice.
作者信息
Grumet F C
出版信息
J Exp Med. 1972 Jan;135(1):110-25. doi: 10.1084/jem.135.1.110.
Abstract
The kinetics of antibody formation after immunization with the synthetic polypeptide poly-L(Tyr, Glu)-poly-D, L-Ala--poly-L-Lys [(T, G)-A--L] in aqueous solution were studied in genetically high (H-2(b)) and low (H-2(k)) responder strains of mice. During the 1st wk after immunization both strains developed brisk primary responses consisting of IgM antibody. With subsequent antigen challenge, only the high responder mice showed immunological memory, producing high titers of IgG antibody. In contrast, the low responder mice continued to make a persistent low level of IgM antibody and appeared unreactive to secondary or tertiary antigen challenge. These data are consistent with the hypothesis that the immune response-1 gene [controlling response to (T, G)-A--L] exerts its effect on the immune response at the time of switchover from IgM to IgG antibody production.
摘要
在遗传上高应答（H-2(b)）和低应答（H-2(k)）的小鼠品系中，研究了用合成多肽聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸[（T，G）-A-L]在水溶液中免疫后抗体形成的动力学。在免疫后的第1周，两个品系都产生了由IgM抗体组成的活跃的初次应答。随后进行抗原攻击时，只有高应答小鼠表现出免疫记忆，产生高滴度的IgG抗体。相比之下，低应答小鼠继续产生持续低水平的IgM抗体，并且对二次或三次抗原攻击似乎无反应。这些数据与免疫反应-1基因[控制对（T，G）-A-L的反应]在从IgM抗体产生转换为IgG抗体产生时对免疫反应发挥作用的假设一致。
相似文献
1
Genetic control of the immune response. A selective defect in immunologic (IgG) memory in nonresponder mice.免疫反应的遗传控制。无反应小鼠免疫（IgG）记忆中的选择性缺陷。
J Exp Med. 1972 Jan;135(1):110-25. doi: 10.1084/jem.135.1.110.
2
Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys.免疫反应的遗传控制。胸腺切除对小鼠针对聚-L（酪氨酰、谷氨酰）-聚-D，L-丙氨酰-聚-L-赖氨酸的初次和二次抗体反应的影响。
J Exp Med. 1972 Jan;135(1):126-35. doi: 10.1084/jem.135.1.126.
3
Genetic control of the immune response. The effect of graft-versus-host reaction on the antibody response to poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys in nonresponder mice.免疫反应的遗传控制。移植物抗宿主反应对无反应小鼠针对聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸抗体反应的影响。
J Exp Med. 1972 Nov 1;136(5):1195-206. doi: 10.1084/jem.136.5.1195.
4
Genetic control of the immune response. Frequency and characteristics of antigen-binding cells in high and low responder mice.免疫反应的遗传控制。高反应性和低反应性小鼠中抗原结合细胞的频率和特征。
J Exp Med. 1973 May 1;137(5):1180-200. doi: 10.1084/jem.137.5.1180.
5
Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.体外抗体应答的细胞与遗传控制。II. 对聚-L-（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸及聚-L-（组氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸的三硝基苯基缀合物的初次IgM应答的Ir基因控制
J Exp Med. 1977 Oct 1;146(4):1096-107. doi: 10.1084/jem.146.4.1096.
6
Genetic control of immune response. The dose of antigen given in aqueous solution is critical in determining which mouse strain is high responder to poly(LTyr, LGlu)-poly(LPro)--poly(LLys).免疫反应的遗传控制。以水溶液形式给予的抗原剂量对于确定哪种小鼠品系对聚（L-酪氨酸，L-谷氨酸）-聚（L-脯氨酸）-聚（L-赖氨酸）是高反应者至关重要。
J Exp Med. 1975 May 1;141(5):1057-72. doi: 10.1084/jem.141.5.1057.
7
8
Cellular and genetic control of antibody responses in vitro. III. Immune response gene regulation of accessory cell function.体外抗体应答的细胞与遗传控制。III. 辅助细胞功能的免疫应答基因调控。
J Exp Med. 1978 Jun 1;147(6):1611-20. doi: 10.1084/jem.147.6.1611.
9
Antigen-specific thymus cell factors in the genetic control of the immune response to poly-(tyrosyl, glutamyl)-poly-D, L-alanyl--poly-lysyl.抗原特异性胸腺细胞因子在对聚（酪氨酰、谷氨酰）-聚-D，L-丙氨酰-聚赖氨酸免疫应答的遗传控制中。
J Exp Med. 1974 Aug 1;140(2):301-12. doi: 10.1084/jem.140.2.301.
10
引用本文的文献
1
In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.免疫反应基因产物抗体的体内效应。I. 用单克隆抗I-A对体液免疫反应进行单倍型特异性抑制。
J Exp Med. 1981 Nov 1;154(5):1694-702. doi: 10.1084/jem.154.5.1694.
2
Circulating B-cells in patients with immunodeficiency.免疫缺陷患者体内的循环B细胞。
Am J Pathol. 1972 Dec;69(3):513-28.
3
Immune responses in vitro. VI. Genetic control of the in vivo-in vitro discrepancies in 19S antibody synthesis.体外免疫反应。VI. 19S抗体合成中体内-体外差异的遗传控制。
J Exp Med. 1972 Nov 1;136(5):1241-57. doi: 10.1084/jem.136.5.1241.
4
Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys.免疫反应的遗传控制。胸腺切除对小鼠针对聚-L（酪氨酰、谷氨酰）-聚-D，L-丙氨酰-聚-L-赖氨酸的初次和二次抗体反应的影响。
J Exp Med. 1972 Jan;135(1):126-35. doi: 10.1084/jem.135.1.126.
5
Genetic control of the immune response: in vitro stimulation of lymphocytes by (T,G)-A--L, (H,G)-A--L, and (Phe,G)-A--L.免疫反应的遗传控制：(T,G)-A--L、(H,G)-A--L和(Phe,G)-A--L对淋巴细胞的体外刺激
J Exp Med. 1974 Oct 1;140(4):977-94. doi: 10.1084/jem.140.4.977.
6
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
7
Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera.豚鼠中组织相容性连锁免疫反应基因的功能。同种异体抗血清对抗原诱导的淋巴细胞增殖的特异性抑制。
J Exp Med. 1972 Nov 1;136(5):1207-21. doi: 10.1084/jem.136.5.1207.
8
Genetic control of the immune response. The effect of graft-versus-host reaction on the antibody response to poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys in nonresponder mice.免疫反应的遗传控制。移植物抗宿主反应对无反应小鼠针对聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸抗体反应的影响。
J Exp Med. 1972 Nov 1;136(5):1195-206. doi: 10.1084/jem.136.5.1195.
9
Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.C3H-CWB四亲本小鼠对聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸抗体反应的遗传控制。
J Exp Med. 1974 Dec 1;140(6):1660-75. doi: 10.1084/jem.140.6.1660.
10
Antigen-specific thymus cell factors in the genetic control of the immune response to poly-(tyrosyl, glutamyl)-poly-D, L-alanyl--poly-lysyl.抗原特异性胸腺细胞因子在对聚（酪氨酰、谷氨酰）-聚-D，L-丙氨酰-聚赖氨酸免疫应答的遗传控制中。
J Exp Med. 1974 Aug 1;140(2):301-12. doi: 10.1084/jem.140.2.301.
本文引用的文献
1
THE IMMUNOGLOBULINS OF MICE. V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES.小鼠的免疫球蛋白。V. 五类免疫球蛋白的代谢（分解代谢）特性
J Exp Med. 1965 Jul 1;122(1):41-58. doi: 10.1084/jem.122.1.41.
2
ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE.细胞水平的抗体合成。抗体对19S和7S抗体反应的抑制作用。
J Exp Med. 1965 Jun 1;121(6):969-89. doi: 10.1084/jem.121.6.969.
3
SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION.关于19S抗体产生的单细胞研究。
J Exp Med. 1964 Mar 1;119(3):485-502. doi: 10.1084/jem.119.3.485.
4
Delayed development of primary immunological responsiveness in neonatally thymectomized swiss albino mice.新生期胸腺切除的瑞士白化小鼠原发性免疫反应性发育延迟。
Clin Exp Immunol. 1967 Nov;2(6):701-4.
5
Immunologic competence after thymectomy.胸腺切除术后的免疫能力。
Int Arch Allergy Appl Immunol. 1966;30(2):105-19. doi: 10.1159/000229800.
6
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
7
Thymus dependence of antibody response: variation with dose of antigen and class of antibody.抗体反应的胸腺依赖性：随抗原剂量和抗体类别而变化
Nature. 1968 Nov 30;220(5170):927-8. doi: 10.1038/220927a0.
8
9
Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs.2号品系豚鼠中多聚-L-赖氨酸基因与控制主要组织相容性抗原的基因座之间的连锁关系。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):322-8. doi: 10.1073/pnas.66.2.322.
10
Evidence for control of synthesis of the varible regions of the heavy chains of immunoglobulins G and M by the same gene.免疫球蛋白G和M重链可变区的合成受同一基因控制的证据。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):337-43. doi: 10.1073/pnas.66.2.337.
Zotero 插件