Mantel N, Bohidar N R, Ciminera J L
Cancer Res. 1977 Nov;37(11):3863-8.
The Mantel-Haenszel procedure for comparing sets of time-to-response data is adaptable to data that can be stratified on other variables. A particular adaptation, which we have used, is one in which animals from the same litter have been assigned to different treatment groups, e.g., some to a control group and some to a drug treatment group. The time to response used was that of tumor appearance; death from other causes was considered a loss to observation. The initial litter-adjusted analysis seemed to have only limited advantages compared to analysis that ignored litters and could be interpreted as suggesting that litter matchihg was not advantageous. Contributing to the difficulty was the fact that in the litter-matched analysis no further information was forthcoming from the remaining similarly treated animals in a litter when there were no remaining contrastingly treated littermates. Several devices for recovering interlitter information from such remnants and for combining it with intralitter information are examined and applied.
用于比较反应时间数据集的Mantel-Haenszel程序适用于可按其他变量分层的数据。我们所采用的一种特殊改编方法是，将来自同一窝的动物分配到不同的治疗组，例如，一些分到对照组，一些分到药物治疗组。所使用的反应时间是肿瘤出现的时间；因其他原因死亡则视为观察失访。与忽略窝别进行的分析相比，最初的窝别调整分析似乎优势有限，这可以解释为表明窝别匹配并无优势。造成困难的一个事实是，在窝别匹配分析中，当没有剩余的对比处理窝伴时，同一窝中其余接受相同处理的动物无法提供更多信息。本文研究并应用了几种从这些残余数据中恢复窝间信息并将其与窝内信息相结合的方法。
