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选择性繁殖大鼠口服吗啡。

Oral intake of morphine in selectively bred rats.

作者信息

Satinder K P

出版信息

Pharmacol Biochem Behav. 1977 Jul;7(1):43-9. doi: 10.1016/0091-3057(77)90008-9.

DOI:10.1016/0091-3057(77)90008-9
PMID:561963
Abstract

Oral intake of morphine was investigated in selectively bred strains of rats. It was possible to induce all the five genetic lines to consume morphine in distilled water. Withdrawal of morphine resulted in significant decrease in the body weights of all the genetic lines in both the experiments. Significant drug-preference behavior was found only in three genetic lines with a common characteristic of relatively high emotional reactivity as compared to the two lines not showing such a behavior.

摘要

在选择性培育的大鼠品系中对口服吗啡进行了研究。有可能诱导所有五个基因系在蒸馏水中摄入吗啡。在两个实验中,停用吗啡导致所有基因系的体重显著下降。仅在三个基因系中发现了显著的药物偏好行为,与另外两个未表现出这种行为的品系相比,这三个基因系具有相对较高情绪反应性的共同特征。

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Oral intake of morphine in selectively bred rats.选择性繁殖大鼠口服吗啡。
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Production of physical dependence in rats by drinking a morphine solution.通过饮用吗啡溶液使大鼠产生身体依赖性。
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Morphine preference in individual rats after morphine ingestion.吗啡摄入后个体大鼠对吗啡的偏好。
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Preference for morphine and drug-seeking behavior in morphine dependent rats.吗啡依赖大鼠对吗啡的偏好及觅药行为
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Voluntary morphine ingestion, morphine dependence, and recovery from withdrawal signs.自愿摄入吗啡、吗啡依赖以及戒断症状的恢复。
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引用本文的文献

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Differences in morphine reinforcement property in two inbred rat strains: associations with cortical receptors, behavioral activity, analgesia and the cataleptic effects of morphine.两种近交系大鼠吗啡强化特性的差异:与皮质受体、行为活动、镇痛及吗啡致僵效应的关联
Psychopharmacology (Berl). 1993;112(2-3):183-8. doi: 10.1007/BF02244908.
2
Opioids and behavior: genetic aspects.阿片类药物与行为:遗传学方面
Experientia. 1988 Jun 15;44(6):473-81. doi: 10.1007/BF01958921.