绵羊对腹腔内免疫的肠道反应。
Intestinal response of sheep to intraperitoneal immunization.
作者信息
Beh K J, Husband A J, Lascelles A K
出版信息
Immunology. 1979 Jun;37(2):385-8.
The aim of the present study was to develop an immunization procedure which centrally stimulated the IgA system of sheep with the release of antibody-containing cells (ACC) of the IgA class into intestinal lymph. It was found that intraperitoneal injection of ovalbumin resulted in a substantial output of ACC in intestinal lymph. ACC of the IgA class reached a peak 8--9 days after intraperitoneal injection when they comprised 1.4% of cells in lymph. ACC of the IgM and IgG1 classes comprised 3.5 and 2.9% of cells in lymph at this time. The output of ACC of the IgA, IgM and IgG1 classes in lymph at the peak of the response was respectively, 3.7 X 10(6), 9.8 X 10(6) and 8 X 10(6) cells/h. In marked contrast to rats, virtually no ACC appeared in intestinal lymph of sheep following intraduodenal infusion of ovalbumin in animals primed 2 weeks earlier by intraperitoneal injection of antigen in Freund's complete adjuvant (CFA).
本研究的目的是开发一种免疫程序，该程序能集中刺激绵羊的IgA系统，使含IgA类抗体的细胞（ACC）释放到肠淋巴中。研究发现，腹腔注射卵清蛋白会导致肠淋巴中ACC大量输出。IgA类ACC在腹腔注射后8 - 9天达到峰值，此时它们占淋巴中细胞的1.4%。此时，IgM和IgG1类ACC分别占淋巴中细胞的3.5%和2.9%。反应峰值时，淋巴中IgA、IgM和IgG1类ACC的输出量分别为3.7×10⁶、9.8×10⁶和8×10⁶个细胞/小时。与大鼠形成显著对比的是，在两周前经腹腔注射弗氏完全佐剂（CFA）中的抗原进行致敏的动物中，十二指肠内注入卵清蛋白后，绵羊的肠淋巴中几乎没有ACC出现。
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