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Intestinal response of sheep to intraperitoneal immunization.绵羊对腹腔内免疫的肠道反应。
Immunology. 1979 Jun;37(2):385-8.
2
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10
IgA-containing cells in the ruminant intestine following intraperitoneal and local immunization.经腹腔和局部免疫后反刍动物肠道中含IgA的细胞
Immunology. 1979 Jul;37(3):597-601.

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Isolation of porcine immunoglobulins and determination of the immunoglobulin classes of transmissible gastroenteritis viral antibodies.猪免疫球蛋白的分离及传染性胃肠炎病毒抗体免疫球蛋白类别的测定。
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The conjugation of immunoglobulins with tetramethylrhodamine isothiocyanate. A comparison between the amorphous and the crystalline fluorochrome.免疫球蛋白与异硫氰酸四甲基罗丹明的共轭作用。无定形荧光染料与结晶荧光染料的比较。
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The secretory antibody response. Anti-DNP antibodies induced by dinitrophenylated type 3 pneumococcus.分泌性抗体反应。由二硝基苯基化3型肺炎球菌诱导产生的抗二硝基苯酚抗体。
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Class specificity of intracellular and surface immunoglobulin of cells in popliteal and intestinal lymph from sheep.绵羊腘窝淋巴结和肠淋巴中细胞内及表面免疫球蛋白的类特异性
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Cellular kinetics of the intestinal immune response to cholera toxoid in rats.大鼠对霍乱类毒素肠道免疫反应的细胞动力学
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绵羊对腹腔内免疫的肠道反应。

Intestinal response of sheep to intraperitoneal immunization.

作者信息

Beh K J, Husband A J, Lascelles A K

出版信息

Immunology. 1979 Jun;37(2):385-8.

PMID:572819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457511/
Abstract

The aim of the present study was to develop an immunization procedure which centrally stimulated the IgA system of sheep with the release of antibody-containing cells (ACC) of the IgA class into intestinal lymph. It was found that intraperitoneal injection of ovalbumin resulted in a substantial output of ACC in intestinal lymph. ACC of the IgA class reached a peak 8--9 days after intraperitoneal injection when they comprised 1.4% of cells in lymph. ACC of the IgM and IgG1 classes comprised 3.5 and 2.9% of cells in lymph at this time. The output of ACC of the IgA, IgM and IgG1 classes in lymph at the peak of the response was respectively, 3.7 X 10(6), 9.8 X 10(6) and 8 X 10(6) cells/h. In marked contrast to rats, virtually no ACC appeared in intestinal lymph of sheep following intraduodenal infusion of ovalbumin in animals primed 2 weeks earlier by intraperitoneal injection of antigen in Freund's complete adjuvant (CFA).

摘要

本研究的目的是开发一种免疫程序，该程序能集中刺激绵羊的IgA系统，使含IgA类抗体的细胞（ACC）释放到肠淋巴中。研究发现，腹腔注射卵清蛋白会导致肠淋巴中ACC大量输出。IgA类ACC在腹腔注射后8 - 9天达到峰值，此时它们占淋巴中细胞的1.4%。此时，IgM和IgG1类ACC分别占淋巴中细胞的3.5%和2.9%。反应峰值时，淋巴中IgA、IgM和IgG1类ACC的输出量分别为3.7×10⁶、9.8×10⁶和8×10⁶个细胞/小时。与大鼠形成显著对比的是，在两周前经腹腔注射弗氏完全佐剂（CFA）中的抗原进行致敏的动物中，十二指肠内注入卵清蛋白后，绵羊的肠淋巴中几乎没有ACC出现。