Ghosal S, Sharma P V, Jaiswal D K
J Pharm Sci. 1978 Jan;67(1):55-60. doi: 10.1002/jps.2600670115.
The whole plant extract of Swertia angustifolia Buch.-Ham., collected at different stages of growth, contained 14 tetraoxygenated and five pentaoxygenated xanthones and xanthone 1-O-glucosides. Of the eight xanthone 1-O-glucosides isolated, five were previously unreported in nature. The xanthones are broadly based on 1,3,5,8- and 1,3,7,8-oxygenated systems, with an added oxygen function at C-4 in some compounds, and represent a number of methoxylated patterns. The content and relative abundance of the free xanthones and their 1-O-glucosides changed with plant growth. These results are the first demonstration of the variation in chemical characters in the different parts of a Swertia species during its ontogeny. The biolgocial significance of these results is appraised.
狭叶獐牙菜（Swertia angustifolia Buch.-Ham.）在不同生长阶段采集的全株提取物含有14种四氧化型和5种五氧化型呫吨酮及呫吨酮1-O-葡萄糖苷。在分离得到的8种呫吨酮1-O-葡萄糖苷中，有5种在自然界中此前未见报道。这些呫吨酮主要基于1,3,5,8-和1,3,7,8-氧化体系，一些化合物在C-4位有额外的氧官能团，并呈现多种甲氧基化模式。游离呫吨酮及其1-O-葡萄糖苷的含量和相对丰度随植物生长而变化。这些结果首次证明了獐牙菜属植物在个体发育过程中不同部位化学特征的变化。对这些结果的生物学意义进行了评估。
