Ghosal S, Biswas K, Chaudhuri R K
J Pharm Sci. 1978 May;67(5):721-2. doi: 10.1002/jps.2600670546.
Anti-Mycobacterium tuberculosis H37 RV data are presented for the individual xanthones of Canscora decussata Schult and Swertia purpurascens Wall (Gentianaceae); a few, from the former species, showed significant activity. Additionally, sturcture--activity relationships of these compounds are evaluated on the basis of the minimum inhibitory concentration data of 18 naturally occurring xanthones bearing 1,3,5- 1,3,5,6-, 1,3,6,7-, 1,3,5,8-, 1,3,5,6,7-, and 1,3.6,7,8-oxygenated patterns and six synthetic analogs.
给出了针对交叉花锚（Canscora decussata Schult）和紫红獐牙菜（Swertia purpurascens Wall，龙胆科）中各氧杂蒽酮的抗结核分枝杆菌H37 RV数据；前一种植物中的少数氧杂蒽酮显示出显著活性。此外，根据18种具有1,3,5-、1,3,5,6-、1,3,6,7-、1,3,5,8-、1,3,5,6,7-和1,3,6,7,8-氧化模式的天然氧杂蒽酮以及六种合成类似物的最低抑菌浓度数据，评估了这些化合物的构效关系。
