迟发型超敏反应。I. 细胞体外暴露于抗原对迟发型超敏反应白细胞转移的影响。
Delayed hypersensitivity. I. Effect of in vitro exposure of cells to antigen upon leukocytic transfer of delayed hypersensitivity.
作者信息
Kantor F S
出版信息
J Exp Med. 1968 Feb 1;127(2):251-61. doi: 10.1084/jem.127.2.251.
Abstract
Exposure to picryl guinea pig albumin with 3-6 picryl groups per mole failed to affect the ability of peritoneal exudate or peripheral blood leukocytes from sensitized donors to transfer delayed sensitivity to normal recipients. In contrast, conjugates containing 40-48 picryl groups per mole altered the ability of exposed leukocytes to transfer delayed sensitivity. Evidence is presented that highly conjugated guinea pig albumin is self-aggregating. Lightly conjugated albumin, previously heat-aggregated, also was effective in "desensitization." The properties of antigen size, cell association of antigen after exposure, and desensitization appear to be associated.
摘要
暴露于每摩尔含3 - 6个苦基的苦基豚鼠白蛋白，不会影响致敏供体的腹腔渗出液或外周血白细胞向正常受体传递迟发型超敏反应的能力。相比之下，每摩尔含40 - 48个苦基的结合物会改变暴露白细胞传递迟发型超敏反应的能力。有证据表明，高度结合的豚鼠白蛋白会自我聚集。先前经热聚集的轻度结合白蛋白在“脱敏”方面也有效。抗原大小、暴露后抗原与细胞的结合以及脱敏的特性似乎是相关的。
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