对简单化合物致敏的免疫无反应性；寻找变应原的抗体吸收库。
IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS; A SEARCH FOR ANTIBODY-ABSORBING DEPOTS OF ALLERGEN.
作者信息
BATTISTO J R, CHASE M W
出版信息
J Exp Med. 1963 Dec 1;118(6):1021-35. doi: 10.1084/jem.118.6.1021.
Abstract
Guinea pigs fed picryl chloride to induce specific immunologic unresponsiveness cleared small amounts of venously infused antipicryl antibody at a rate equal to that of normal guinea pigs. Catabolism of passively administered picryl-specific antibody did not alter the unresponsive state of picryl chloride-fed guinea pigs or the responsive state of normal guinea pigs. Lymphoid cells of picryl chloride immunized guinea pigs produced equal amounts of picryl-specific antibody in picryl chloride-fed and normal animals. Allergen-fed guinea pigs remained unresponsive to attempted sensitization with the allergen in excess of 10 months after the final feeding, though some became feebly sensitive between 9 and 11 months. Second attempts to make unresponsive animals hypersensitive were unsuccessful. White blood cells of guinea pigs unresponsive to picryl chloride were unable to transfer delayed-type hypersensitivity for picryl chloride to normal recipients yet readily transferred tuberculin hypersensitivity.
摘要
用苦味酰氯喂养豚鼠以诱导特异性免疫无反应性，这些豚鼠清除静脉注入的抗苦味酰抗体的量与正常豚鼠相同。被动给予的苦味酰特异性抗体的分解代谢并未改变用苦味酰氯喂养的豚鼠的无反应状态或正常豚鼠的反应状态。用苦味酰氯免疫的豚鼠的淋巴细胞在用苦味酰氯喂养的动物和正常动物中产生等量的苦味酰特异性抗体。在最后一次喂食超过10个月后，用变应原喂养的豚鼠对用该变应原进行致敏的尝试仍无反应，尽管有些豚鼠在9至11个月之间变得轻度敏感。再次尝试使无反应动物产生超敏反应未成功。对苦味酰氯无反应的豚鼠的白细胞无法将对苦味酰氯的迟发型超敏反应转移给正常受体，但能轻易转移结核菌素超敏反应。
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