3,3-螺双-5-甲基-5'-烷基氨甲基-四氢呋喃酮-2的衍生物作为潜在的神经营养剂。II.
Derivatives of 3.3-spiro-bi-5-methyl-5'-alkylaminomethyl-tetrahydrofuranone-2 as potential neurotropic agents. II.
作者信息
Wagner E, Bobrański B
出版信息
Pol J Pharmacol Pharm. 1977 Sep-Oct;29(5):565-9.
PMID:563594
Abstract
Dilactone of gamma-bromo-beta-hydroxypropyl-beta-hydroxypropyl malonic acid 2 was prepared. By condensation with secondary or primary amines the tertiary amines 3--7. resp. the secondary amines 8--10 were obtained. The reaction of 2 with tertiary amines gave the corresponding ammonium salts 11--12. All the compounds are subjected to pharmacological examination.
摘要
制备了γ-溴-β-羟丙基-β-羟丙基丙二酸二内酯2。通过与仲胺或伯胺缩合，分别得到叔胺3-7和仲胺8-10。2与叔胺反应得到相应的铵盐11-12。所有化合物均进行了药理检查。
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