Miller S C, Kaiserman M, Osmond D G
Experientia. 1978 Jan 15;34(1):129-31. doi: 10.1007/BF01921944.
In mice given 3H-thymidine systemically during temporary circulatory occlusion of one hind limb, comparison of the labeling of rapidly-renewing small lymphocytes in the tibial marrows demonstrated that these cells were locally produced. Labeling by 3H-thymidine infusion revealed that many marrow large lymphoid cells, presumptive small lymphocyte progenitors, had a marked proliferative activity and rapid turnover which varied according to cell size, was maximal in young mice and declined with increasing age.
在对一只后肢进行暂时性循环阻断期间全身给予3H-胸腺嘧啶核苷的小鼠中，比较胫骨骨髓中快速更新的小淋巴细胞的标记情况表明，这些细胞是在局部产生的。通过3H-胸腺嘧啶核苷输注进行标记显示，许多骨髓大淋巴细胞（推测为小淋巴细胞祖细胞）具有显著的增殖活性和快速更新能力，其随细胞大小而变化，在幼鼠中最大，并随年龄增长而下降。
