Nelstrop A E, Taylor G, Collard P
Immunology. 1968 Mar;14(3):347-56.
The clearance of a secondary dose of T bacteriophage from the circulation of the goldfish, lamprey and shore crab has been shown to be more rapid than the clearance of a primary dose of phage. The phenomenon occurs in the absence of any detectable humoral antibody and appears similar to that previously described in rabbits. The effect could not be demonstrated in the dogfish or land snail and it appears possible that some form of immunological paralysis or blockade occurred in these animals. The results suggest that a phylogenetically more primitive immune response than the production of humoral antibody may exist in the animal kingdom.
已表明,二次剂量的T噬菌体从金鱼、七鳃鳗和岸蟹血液循环中的清除速度比初次剂量噬菌体的清除速度更快。这种现象在没有任何可检测到的体液抗体的情况下发生,并且似乎与先前在兔子中描述的现象相似。在角鲨或陆地蜗牛中未观察到这种效应,并且在这些动物中似乎有可能发生了某种形式的免疫麻痹或阻断。结果表明,在动物界可能存在一种在系统发育上比体液抗体产生更为原始的免疫反应。