部分同步化后口腔和口咽不可切除鳞状细胞癌的放射治疗
Irradiation treatment of inoperable squamous cell carcinomas of the oral cavity and oropharynx after partial synchronisation.
作者信息
Esser E, Schumann J, Wannenmacher M
出版信息
J Maxillofac Surg. 1976 Mar;4(1):26-33. doi: 10.1016/s0301-0503(76)80005-7.
PMID:56413
Abstract
Bleomycin has proved to be an efficacious cyclus-synchronising drug in the sense that it arrests the radiosensitive G2-phase directly. In comparison with 5-Fluor-uracil, Bleomycin possesses a more effective cell-kinetics. An analytical clinical remission with the application of Bleomycin, coupled with a higher incidence of local and general side effects.
摘要
博来霉素已被证明是一种有效的细胞周期同步药物，因为它能直接阻断对辐射敏感的G2期。与5-氟尿嘧啶相比，博来霉素具有更有效的细胞动力学。应用博来霉素可实现分析性临床缓解，但局部和全身副作用的发生率较高。
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