Esser E, Schumann J, Wannenmacher M
Dtsch Zahnarztl Z. 1975 Mar;30(3):222-30.
A therapeutical method of inoperable squamous cell carcinomas based on cell kinetics has been applied since 1969 by using 5-fluorine-uracil. Impulse cytophotometric tests did not confirm the degree of partial synchronization due to 5FU that had been assumed so far on the basis of autoradiographic techniques. The results obtained in 46 patients with inoperable malignant epithelial tumors of the maxillo-facial region that were better than those obtained with radiological therapy only, can to a certain extent be contributed to 5FU. First impulse cytophotometric findings in biopsies of animal and human tumors show that Bleomycin clearly produced partial synchronization due to a reversible stop in the radiation-sensitive G2 phase.
自1969年以来，一种基于细胞动力学的不可切除鳞状细胞癌治疗方法被应用，即使用5-氟尿嘧啶。脉冲细胞光度测试并未证实因5-氟尿嘧啶而产生的部分同步化程度，而到目前为止，这一程度是基于放射自显影技术所假定的。在46例颌面部区域不可切除恶性上皮肿瘤患者中所获得的结果优于仅采用放射治疗所获得的结果，这在一定程度上可归因于5-氟尿嘧啶。动物和人类肿瘤活检的首次脉冲细胞光度测定结果表明，博来霉素由于在对辐射敏感的G2期出现可逆性停滞而明显产生了部分同步化。
