亚急性细菌性心内膜炎中血清调理素、细菌及多形核白细胞的相互作用。抗γ球蛋白因子及其与特异性调理素的相互作用。
Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.
作者信息
Messner R P, Laxidal T, Quie P G, Williams R C
出版信息
J Clin Invest. 1968 May;47(5):1109-20. doi: 10.1172/JCI105800.
The effect of anti-gamma-globulin factors on 7S gamma-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-gamma-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S gamma-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human gammaG globulin. The antiopsonic effect of anti-gamma-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-gamma-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.
已使用定量体外吞噬系统研究了抗γ球蛋白因子对亚急性细菌性心内膜炎患者7Sγ球蛋白调理素的作用。来自亚急性细菌性心内膜炎和类风湿性关节炎患者的人抗γ球蛋白因子特异性抑制了与细菌特异性结合的7Sγ球蛋白的调理作用。用兔抗人γG球蛋白抗血清也获得了类似的抗调理作用。抗γ球蛋白因子的抗调理作用与其增强7S抗体对细菌凝集作用的能力无关。已证明抗γ球蛋白因子的抗调理作用与含有溶血活性补体的热不稳定血清因子的促吞噬作用之间存在竞争。
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