Wisser J, Horster M
Pflugers Arch. 1978 Feb 22;373(2):205-8. doi: 10.1007/BF00584862.
Net fluid flux and transmural hydrostatic hydraulic conductance (Lp) were measured in the rat ileum during postnatal ontogeny, utilizing a refined in vitro, capillary-perfused (non-isolated) preparation for free-flow studies. Volume absorption at low transmural pressure gradient (1-2 cmH2O) was 0.99 +/- 0.22 ml/g wet weight.hr in the mature ileum and 1.55 +/- 0.42 ml/g wwt.hr in the differentiating intestine. Hydrostatic hydraulic conductance of the mature ileum was 0.76 microliter/cm2.cm H2O.hr, indicating that normal hydrostatic pressure gradients are not important for modulation of intestinal absorption. In contrast, Lp was 3.82 microliter/cm2.cmH2O.hr in the differentiating ileu, suggesting a significant contribution of pressure-dependent solvent drag to isotonic solute absorption.
在出生后的个体发育过程中，利用一种改进的体外毛细血管灌注（非离体）制剂进行自由流动研究，测量大鼠回肠的净液体通量和跨壁静水液压传导率（Lp）。在低跨壁压力梯度（1 - 2 cmH₂O）下，成熟回肠的体积吸收为0.99±0.22 ml/g湿重·小时，而在分化中的肠道为1.55±0.42 ml/g湿重·小时。成熟回肠的静水液压传导率为0.76微升/cm²·cmH₂O·小时，这表明正常的静水压力梯度对肠道吸收的调节并不重要。相比之下，分化中的回肠Lp为3.82微升/cm²·cmH₂O·小时，这表明压力依赖性溶剂拖曳对等渗溶质吸收有显著贡献。
