胸腺瘤患者重症肌无力的自发缓解

Spontaneous remission of myasthenia gravis in patients with thymoma.

作者信息

Masaoka A, Monden Y, Seike Y

出版信息

Neurology. 1978 May;28(5):495-6. doi: 10.1212/wnl.28.5.495.

DOI:10.1212/wnl.28.5.495

Abstract

In 42 cases of myasthenia gravis with thymoma, the tumor was removed surgically. In four of these cases, myasthenic symptoms had remitted before operation. However, in two of these four cases, myasthenic symptoms returned after operation, despite apparently total thymectomy. In two of the four cases that remitted before operation, the thymus was found to be highly involuted, without germinal centers; in another case, the thymus was found to be moderately involuted, and germinal centers were found. In the nonrelapsing cases, only the tumor itself was removed, with residual thymic tissue being left behind. The thymoma in all cases consisted of polygonal epithelial cells and lymphocytes.

摘要

在42例伴有胸腺瘤的重症肌无力患者中，肿瘤通过手术切除。在其中4例中，肌无力症状在手术前已缓解。然而，在这4例中的2例中，尽管胸腺切除术看似彻底，但肌无力症状在术后又复发了。在术前缓解的4例中的2例中，发现胸腺高度萎缩，无生发中心；在另一例中，发现胸腺中度萎缩，并有生发中心。在未复发的病例中，仅切除了肿瘤本身，残留了胸腺组织。所有病例中的胸腺瘤均由多角形上皮细胞和淋巴细胞组成。