与母亲甲状旁腺功能亢进相关的新生儿低钙血症。新的发病机制观察。
Neonatal hypocalcaemia associated with maternal hyperparathyroidism. New pathogenetic observations.
作者信息
Jacobsen B B, Terslev E, Lund B, Sørensen O H
出版信息
Arch Dis Child. 1978 Apr;53(4):308-11. doi: 10.1136/adc.53.4.308.
A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatment with calcium and vitamin D, serum PTH and 25-OHD3 concentrations increased markedly before serum calcium levels returned to normal perhaps indicating an inability to convert 25-OHD3 to the metabolically active 1,25-dihyroxyvitamin D3 during the hyperphosphataemic state. Treatment with 1,25-dihdroxyvitamin D3 or its analogues is recommended.
一名32日龄男婴出现低钙惊厥，与无症状的母亲甲状旁腺功能亢进有关。入院时发现血清总钙和离子钙水平极低，血清磷酸盐升高，血清甲状旁腺激素（PTH）和25-羟胆钙化醇（25-OHD3）浓度正常。经钙和维生素D治疗后，血清钙水平恢复正常之前，血清PTH和25-OHD3浓度显著升高，这可能表明在高磷血症状态下无法将25-OHD3转化为具有代谢活性的1,25-二羟维生素D3。建议使用1,25-二羟维生素D3或其类似物进行治疗。
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