Pediatrics Department, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
Pediatrics Department, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal.
BMJ Case Rep. 2022 Mar 16;15(3):e248262. doi: 10.1136/bcr-2021-248262.
Hypocalcaemia in neonates can range from asymptomatic to a potentially life-threatening condition. We present a case of a 36 weeks gestational age boy, admitted to our neonatal intensive care unit for jitteriness, mild hypotonia and breastfeeding difficulties. By the ninth day of life, he presented with late-onset hypocalcaemia, hypomagnesaemia, low 25-OH-vitamin D and inappropriately normal parathyroid hormone. Further investigation revealed maternal hypercalcaemia with high parathyroid hormone. Maternal asymptomatic hyperparathyroidism was diagnosed and admitted as the cause of neonatal hypocalcaemia. There was a clinical improvement and calcium levels stabilisation after treatment with calcium gluconate and vitamin D This case highlights the importance of careful evaluation of neonatal late-onset hypocalcaemia in uncovering asymptomatic maternal hyperparathyroidism.
新生儿低钙血症的症状范围从无症状到潜在的危及生命的情况。我们报告了一例 36 周胎龄的男婴,因震颤、轻度肌张力低下和母乳喂养困难而入住新生儿重症监护病房。在出生后的第 9 天,他出现了迟发性低钙血症、低镁血症、25-羟维生素 D 水平低和甲状旁腺激素水平正常但不适当。进一步的检查显示母亲高钙血症伴甲状旁腺激素升高。诊断为母亲无症状性甲状旁腺功能亢进症,是新生儿低钙血症的病因。在使用葡萄糖酸钙和维生素 D 治疗后,临床症状改善,血钙水平稳定。本例强调了仔细评估新生儿迟发性低钙血症在发现无症状性母体甲状旁腺功能亢进症中的重要性。