Balster R L, Chait L D
Eur J Pharmacol. 1978 Apr 15;48(4):445-50. doi: 10.1016/0014-2999(78)90173-5.
In two separate experiments a 9 point rating scale was used to assess the effects of various doses of phencyclidine on the behavioral stereotypy produced by d-amphetamine in rats. A dose of phencyclidine (2.5 mg/kg) which had no effect when given alone, enhanced the behavioral effects of 1 and 3 mg/kg of d-amphetamine. Higher dises (5 and 10 mg/kg) of phencyclidine produced some stereotypy when given alone but they also produced ataxia which confounded the rating of their other behavioral effects. These higher doses did not enhance the effects of d-amphetamine. This study provides further evidence that phencyclidine may have dopaminergic activity similar to amphetamine.
在两项独立实验中，采用9分制评分量表评估不同剂量苯环利定对大鼠中右旋苯丙胺所致行为刻板症的影响。单独给予时无作用的苯环利定剂量（2.5毫克/千克）增强了1毫克/千克和3毫克/千克右旋苯丙胺的行为效应。较高剂量（5毫克/千克和10毫克/千克）的苯环利定单独给予时会产生一些刻板症，但也会导致共济失调，这混淆了对其其他行为效应的评分。这些较高剂量并未增强右旋苯丙胺的效应。本研究进一步证明苯环利定可能具有与苯丙胺类似的多巴胺能活性。
