Struthers B J, Hopkins D T, Prescher E E, Dahlgren R R
J Nutr. 1978 Jun;108(6):954-8. doi: 10.1093/jn/108.6.954.
Diets containing 5% to 30% of an alkali-treated isolated soybean protein (ATSP) containing 1% lysinoalanine (LAL) were fed to female Sprague-Dawley rats during gestation and lactation to provide 500, 1,000, 2,000, or 3,000 ppm LAL in the diet. An isolated soybean protein containing no LAL was used as control. No teratological effects were observed. No significant differences in birth weight, mortality, live births/litter, or number of pups/litter was found at any LAL level fed. However, significantly decreased weight gains were observed in pups from dams fed either 2,000 or 3,000 ppm LAL. No LAL was found in the milk, and protein content of all milks was similar. The decreased weight gains appeared to be due to reduced milk production in dams fed high levels of ATSP.
在妊娠和哺乳期，给雌性斯普拉格 - 道利大鼠喂食含有5%至30%碱处理分离大豆蛋白（ATSP）且含有1%赖氨酰丙氨酸（LAL）的日粮，以使日粮中LAL含量达到500、1000、2000或3000 ppm。使用不含LAL的分离大豆蛋白作为对照。未观察到致畸作用。在任何喂食的LAL水平下，出生体重、死亡率、每窝活产数或每窝幼崽数均未发现显著差异。然而，在喂食2000或3000 ppm LAL的母鼠所产幼崽中，观察到体重增加显著下降。在乳汁中未发现LAL，且所有乳汁的蛋白质含量相似。体重增加下降似乎是由于喂食高水平ATSP的母鼠产奶量减少所致。
