生长激素释放抑制激素对人体中速尿诱导的高肾素血症的抑制作用。

Inhibition of frusemide-induced hyperreninaemia by growth-hormone release-inhibiting hormone in man.

作者信息

Rosenthal J, Raptis S, Escobar-Jimenez F, Pfeiffer E F

出版信息

Lancet. 1976 Apr 10;1(7963):772-4. doi: 10.1016/s0140-6736(76)91611-1.

Abstract

In a study of the effect of somatostatin (growth-hormone release-inhibiting hormone) on plasma-renin in healthy volunteers, plasma-renin activity was measured by radioimmunoassay after the intravenous administration of somatostatin and also during frusemide-induced hyperreninaemia. While somatostatin was being given, basal values of renin were unchanged. Injection of frusemide alone produced hyperreninaemia; but, under somatostatin, renin release was inhibited by 45%. The results indicate that somatostatin is a potent inhibitor of renin and exerts its effect independent of sodium excretion, which was unchanged under somatostatin. Conceivably, somatostatin plays an important role in the regulation of endogenous renin release.

摘要

在一项关于生长抑素（生长激素释放抑制激素）对健康志愿者血浆肾素影响的研究中，通过放射免疫分析法在静脉注射生长抑素后以及在速尿诱导的高肾素血症期间测量血浆肾素活性。在给予生长抑素期间，肾素的基础值未发生变化。单独注射速尿会产生高肾素血症；但是，在生长抑素作用下，肾素释放受到45%的抑制。结果表明，生长抑素是肾素的强效抑制剂，其作用独立于钠排泄，在生长抑素作用下钠排泄未发生变化。可以想象，生长抑素在内源性肾素释放的调节中发挥着重要作用。