Dyer R S, Eccles C U, Annau Z
Pharmacol Biochem Behav. 1978 Feb;8(2):137-41. doi: 10.1016/0091-3057(78)90330-1.
Pregnant hooded rats were administered either 5 mg/kg CH3, Hg or 0 mg/kg CH3 Hg by gastric intubation on day seven of gestation. Female offspring were implanted with recording electrodes 60 days after birth and had their cortically recorded visual evoked potentials studied at four different flash intensities. Mercury exposed animals had higher P1-N1 and N1-P2 amplitudes and shorter P2 and N2 latencies than controls. The data provides evidence that a single ingestion of CH3 Hg by pregnant rats is sufficient to produce long term alterations in CNS activity.
在妊娠第7天，通过胃内插管给怀孕的有头罩大鼠分别施用5毫克/千克的甲基汞或0毫克/千克的甲基汞。雌性后代在出生60天后植入记录电极，并在四种不同的闪光强度下研究其皮层记录的视觉诱发电位。与对照组相比，接触汞的动物的P1-N1和N1-P2波幅更高，P2和N2潜伏期更短。数据表明，怀孕大鼠单次摄入甲基汞足以对中枢神经系统活动产生长期改变。
