Worwood M, Taylor D M, Hunt A H
Br Med J. 1968 Aug 10;3(5614):344-6. doi: 10.1136/bmj.3.5614.344.
The presence of large amounts of copper in the liver in primary biliary cirrhosis has been confirmed; a similar increase is not found in cases of long-standing extrahepatic biliary obstruction. The serum caeruloplasmin levels are raised in primary and secondary biliary cirrhosis, but this increase does not appear to be related to the degree of increase of hepatic copper. The manganese content of the liver is slightly raised in both these conditions.The reason for the increased metal content in these circumstances cannot yet be determined, and the effects are not yet understood.
原发性胆汁性肝硬化患者肝脏中存在大量铜已得到证实；在长期肝外胆管梗阻病例中未发现类似的升高情况。原发性和继发性胆汁性肝硬化患者血清铜蓝蛋白水平均升高，但这种升高似乎与肝脏铜含量的增加程度无关。在这两种情况下，肝脏中的锰含量均略有升高。目前尚无法确定在这些情况下金属含量增加的原因，其影响也尚不明确。
