Horne C H, White R G
Immunology. 1968 Jul;15(1):65-74.
The use of the intra-lymph node injection route for a range of doses of ovalbumin (antigen) and mycobacterial peptidoglycolipid (adjuvant) in water-in-oil emulsion failed to show any superiority of this method over the usual footpad injection, in terms of induction of cell-mediated hypersensitivity. The same result applied to anti-ovalbumin antibody levels in the serum at 3 weeks after injection, the findings with lower doses of ovalbumin were that lower levels of anti-ovalbumin resulted when the intra-lymph node injection route was used. For the induction of allergic encephalomyelitis the intra-lymph node injection route failed to prove superior to the footpad route at several dose-levels of mycobacterial peptidoglycolipid in water-in-oil emulsion with homologous brain tissue.
对于一系列剂量的卵清蛋白（抗原）和分枝杆菌肽糖脂（佐剂）在油包水乳剂中的情况，就细胞介导的超敏反应诱导而言，使用淋巴结内注射途径并未显示出该方法比通常的足垫注射有任何优势。同样的结果也适用于注射后3周血清中的抗卵清蛋白抗体水平，低剂量卵清蛋白的研究结果表明，使用淋巴结内注射途径时抗卵清蛋白水平较低。对于变应性脑脊髓炎的诱导，在油包水乳剂中与同源脑组织混合的分枝杆菌肽糖脂的几个剂量水平下，淋巴结内注射途径并未证明优于足垫途径。
