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百日咳博德特氏菌疫苗对通过淋巴结内途径或后足垫接种免疫的大鼠实验性甲状腺炎发展的影响。

The effect of Bordetella pertussis vaccine on the development of experimental thyroiditis in rats immunized by the intra-lymph node route or into a hind footpad.

作者信息

Kalden J R, Williamson W G, Irvine W J

出版信息

Clin Exp Immunol. 1969 Nov;5(5):549-53.

PMID:4902606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1579134/
Abstract

Experimental thyroiditis was produced by a single injection of homologous thyroglobulin in Freund's complete adjuvant when this was given along with an intracutaneous injection of vaccine. Severe thyroid lesions were observed as early as 8 days. There was no significant difference in the incidence and severity of thyroiditis and antibody formation when the thyroglobulin was injected into lymph nodes or into a hind footpad.

摘要

当将同源甲状腺球蛋白单次注射于弗氏完全佐剂中，并同时进行皮内疫苗注射时，可引发实验性甲状腺炎。早在第8天就观察到了严重的甲状腺病变。当将甲状腺球蛋白注入淋巴结或后足垫时，甲状腺炎的发生率和严重程度以及抗体形成方面均无显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0180/1579134/87de10fc3589/clinexpimmunol00336-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0180/1579134/87de10fc3589/clinexpimmunol00336-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0180/1579134/87de10fc3589/clinexpimmunol00336-0109-a.jpg

相似文献

1
The effect of Bordetella pertussis vaccine on the development of experimental thyroiditis in rats immunized by the intra-lymph node route or into a hind footpad.百日咳博德特氏菌疫苗对通过淋巴结内途径或后足垫接种免疫的大鼠实验性甲状腺炎发展的影响。
Clin Exp Immunol. 1969 Nov;5(5):549-53.
2
Passive transfer of experimental autoimmune thyroiditis from donor rabbits injected with soluble thyroglobulin without adjuvant.将未添加佐剂的可溶性甲状腺球蛋白注射到供体兔体内，被动转移实验性自身免疫性甲状腺炎。
Int Arch Allergy Appl Immunol. 1967;32(5):506-20. doi: 10.1159/000229962.
3
Autoimmunity in methylcholanthrene-induced and spontaneous thyroiditis in Buffalo strain rats.甲基胆蒽诱导的和布法罗品系大鼠自发性甲状腺炎中的自身免疫
Proc Soc Exp Biol Med. 1971 Nov;138(2):579-84. doi: 10.3181/00379727-138-35945.
4
Murine thyroiditis. 3. Influence of syngeneic and allogeneic thyroid antigen on induction of the disease.小鼠甲状腺炎。3. 同基因和异基因甲状腺抗原对疾病诱导的影响。
Clin Exp Immunol. 1972 Jun;11(2):245-54.
5
Factors affecting transfer of experimental autoimmune thyroiditis in rats.影响大鼠实验性自身免疫性甲状腺炎转移的因素。
Immunology. 1973 May;24(5):859-70.
6
[Immune reactions of lymphocytes to heterologous thyroglobulin in experimental immune thyroiditis of the guinea pig].[豚鼠实验性免疫性甲状腺炎中淋巴细胞对异种甲状腺球蛋白的免疫反应]
Z Immunitatsforsch Allerg Klin Immunol. 1970;140(3):304-12.
7
Perpetuation of autoimmune thyroiditis and production of secondary renal lesions following periodic injections of aqueous preparations of altered thyroglobulin.通过定期注射经改变的甲状腺球蛋白水性制剂来维持自身免疫性甲状腺炎并产生继发性肾脏病变。
Clin Exp Immunol. 1969 Jun;4(6):645-57.
8
Experimental allergic thyroiditis in rats: suppression by heterologous (rabbit) anti-lymphocyte sera to lymph node, thymic and splenic lymphocytes.大鼠实验性变应性甲状腺炎：用针对淋巴结、胸腺和脾淋巴细胞的异种（兔）抗淋巴细胞血清抑制
Clin Exp Immunol. 1970 Feb;6(2):273-8.
9
Spontaneous thyroiditis in an obese strain of chickens. II. Investigations on the development of the disease.肥胖品系鸡的自发性甲状腺炎。II. 疾病发展的研究。
J Immunol. 1969 Dec;103(6):1331-41.
10
Sites of autoantibody production in rats with thyroiditis.甲状腺炎大鼠自身抗体产生的部位。
Immunology. 1982 Jun;46(2):465-72.

本文引用的文献

1
Simple method for enhancing development of acute disseminated encephalomyelitis in mice.增强小鼠急性播散性脑脊髓炎发展的简易方法。
Proc Soc Exp Biol Med. 1955 Jun;89(2):263-6. doi: 10.3181/00379727-89-21778.
2
LYMPHATIC DRAINAGE AND ADJUVANT-INDUCED ARTHRITIS IN RATS.大鼠的淋巴引流与佐剂诱导性关节炎
Br J Exp Pathol. 1964 Aug;45(4):375-83.
3
Rapid induction of experimental allergic thyroiditis in rats sensitized to thyroid-adjuvant and pertussis vaccine.
J Immunol. 1968 Nov;101(5):1098-101.
4
The suppression of experimental thyroiditis in the rat by heterologous anti-lymphocyte globulin.用异种抗淋巴细胞球蛋白抑制大鼠实验性甲状腺炎
Clin Exp Immunol. 1968 Nov;3(9):973-81.
5
Immunologically induced aspermatogenesis in the white mouse.白色小鼠中免疫诱导的无精子症
J Immunol. 1968 Aug;101(2):374-6.
6
Evaluation of the direct injection of antigen into a peripheral lymph node for the production of humoral and cell-mediated immunity in the guinea-pig.评估将抗原直接注射到豚鼠外周淋巴结中以产生体液免疫和细胞介导免疫的效果。
Immunology. 1968 Jul;15(1):65-74.
7
The production and passive transfer of allergic adrenalitis.变应性肾上腺炎的产生与被动转移
Am J Pathol. 1968 Jan;52(1):41-54.