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精胺在肝脏再生中的作用:与核糖核酸的快速合成有关。

Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid.

出版信息

Science. 1965 Jul 23;149(3682):428-9. doi: 10.1126/science.149.3682.428.

DOI:10.1126/science.149.3682.428
PMID:17809408
Abstract

The spermidine in rat liver increases after partial hepatectomy, and the rate of polyamine accumulation closely approximates the increased rate of synthesis of RNA in regenerating liver. The uptake by the liver of intravenously injected putrescine and the biosynthesis of spermidine are accelerated within 2 hours after the operation. The uptake of spermidine also increases during early regeneration.

摘要

大鼠肝部分切除后精脒增加,多胺积累的速度与肝再生中 RNA 合成的增加速度密切接近。手术后 2 小时内,肝对静脉注射腐胺的摄取和精脒的生物合成加速。在早期再生过程中,精脒的摄取也增加。

相似文献

1
Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid.精胺在肝脏再生中的作用:与核糖核酸的快速合成有关。
Science. 1965 Jul 23;149(3682):428-9. doi: 10.1126/science.149.3682.428.
2
Polyamine metabolism in regenerating livers from normal and hypocalcemic rats.正常和低钙血症大鼠再生肝脏中的多胺代谢
J Cell Physiol. 1978 Jan;94(1):87-91. doi: 10.1002/jcp.1040940111.
3
Aging alters ornithine decarboxylase and decreases polyamines in regenerating rat liver but putrescine replacement has no effect.衰老会改变鸟氨酸脱羧酶,并降低再生大鼠肝脏中的多胺水平,但腐胺替代没有效果。
J Lab Clin Med. 1992 Jan;119(1):38-47.
4
[Reversible disorder of polyamine and DNA synthesis in regenerating rat liver].[再生大鼠肝脏中多胺与DNA合成的可逆性紊乱]
Biull Eksp Biol Med. 1980 Aug;90(8):165-7.
5
Human erythrocyte polyamine levels after partial hepatectomy.部分肝切除术后人体红细胞多胺水平
Hepatogastroenterology. 1997 May-Jun;44(15):744-50.
6
[Effects of single ethanol administration on liver regeneration in rats].[单次给予乙醇对大鼠肝脏再生的影响]
Arukoru Kenkyuto Yakubutsu Ison. 1991 Oct;26(5):380-90.
7
Effect of ethanol on polyamine synthesis during liver regeneration in rats.乙醇对大鼠肝脏再生过程中多胺合成的影响。
J Clin Invest. 1990 Feb;85(2):385-90. doi: 10.1172/JCI114450.
8
[Dynamics of the elevation of hepatic polyamines after partial hepatectomy in the rat].[大鼠部分肝切除术后肝脏多胺升高的动态变化]
C R Seances Soc Biol Fil. 1980;174(1):58-62.
9
Human erythrocyte polyamine levels after portal vein embolization.门静脉栓塞术后人体红细胞多胺水平
Hepatogastroenterology. 1999 Nov-Dec;46(30):3178-83.
10
Quantitative changes of the two major AgNOR proteins, nucleolin and protein B23, related to stimulation of rDNA transcription.与核糖体DNA转录激活相关的两种主要银染核仁组织区蛋白(核仁素和蛋白质B23)的定量变化。
Exp Cell Res. 1995 Jul;219(1):276-82. doi: 10.1006/excr.1995.1228.

引用本文的文献

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Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins.将老年可塑性解析为年轻化因子和衰老因子的平衡。
Aging Dis. 2022 Dec 1;13(6):1664-1714. doi: 10.14336/AD.2022.0414.
2
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer.癌症药物预防:针对多胺代谢来管理结肠癌的风险因素。
J Biol Chem. 2018 Nov 30;293(48):18770-18778. doi: 10.1074/jbc.TM118.003343. Epub 2018 Oct 24.
3
Influence of diamines and polyamines on the senescence of plant suspension cultures.二胺和多胺对植物悬浮培养物衰老的影响。
Plant Cell Rep. 1983 Apr;2(2):82-4. doi: 10.1007/BF00270171.
4
Polyamines and nucleic acid metabolism in chick embryo. Incorporation of labelled precursors into nucleic acids of subcellular fractions and polyribosomal patterns.雏鸡胚胎中的多胺和核酸代谢。标记前体在亚细胞成分和多核糖体图谱中的核酸掺入。
Biochem J. 1968 May;107(5):609-13. doi: 10.1042/bj1070609.
5
The role of polyamines in liver regeneration after hepatectomy with ischemic injury.多胺在肝切除术后伴有缺血性损伤的肝再生中的作用。
Surg Today. 1997;27(9):833-9. doi: 10.1007/BF02385274.
6
The increase in putrescine content in the gastric mucosa of rats with ulcerations induced by restraint-immersion stress.束缚-浸水应激诱导溃疡的大鼠胃黏膜中腐胺含量的增加。
Gastroenterol Jpn. 1981;16(1):1-8. doi: 10.1007/BF02820418.
7
Polyamines enhance readthrough of the UGA termination codon in a mammalian messenger RNA.多胺增强哺乳动物信使核糖核酸中UGA终止密码子的通读。
Mol Gen Genet. 1983;190(2):336-43. doi: 10.1007/BF00330661.
8
Isolation of rat mammary epithelial cells for polyamine analysis.用于多胺分析的大鼠乳腺上皮细胞的分离
Biochem J. 1984 Nov 1;223(3):929-32. doi: 10.1042/bj2230929.
9
Rapid effects of testosterone in prostatic polyamine-synthesizing enzyme systems.睾酮对前列腺多胺合成酶系统的快速作用。
Biochem J. 1968 Sep;109(3):32P-33P. doi: 10.1042/bj1090032pb.
10
Biosynthesis of putrescine in the prostate gland of the rat.大鼠前列腺中腐胺的生物合成
Biochem J. 1968 Jul;108(4):533-9. doi: 10.1042/bj1080533.