佝偻病骨骼的胶原蛋白合成与碳水化合物代谢
Collagen synthesis and carbohydrate metabolism of rachitic bone.
作者信息
Paterson C R, Fourman P
出版信息
Biochem J. 1968 Aug;109(1):101-6. doi: 10.1042/bj1090101.
Abstract
- This paper reports studies on the metabolism of bone from normal chicks and from chicks with vitamin D-deficiency rickets. Both in vitro and in vivo there was an increased incorporation of [(14)C]proline into collagen hydroxyproline by rachitic bone. The proportion of the collagen that was soluble in cold salt solutions was greater with the rachitic bone. These results show that in rickets there is an increased synthesis of bone collagen, but they do not provide any evidence of a defect in the maturation of collagen. 2. Rachitic bone incubated aerobically in vitro consumed more glucose and released more lactate than normal bone. Bone from rachitic chicks treated with vitamin D 48hr. previously had rates of glycolysis that were nearly normal. Though we were unable to show any direct action of vitamin D in vitro, we consider that vitamin D probably has a direct action on bone, possibly related to matrix biosynthesis.
摘要
- 本文报道了对正常雏鸡和患维生素D缺乏性佝偻病雏鸡骨骼代谢的研究。无论是在体外还是体内，佝偻病骨骼中[(14)C]脯氨酸掺入胶原羟脯氨酸的量都增加了。佝偻病骨骼中可溶于冷盐溶液的胶原蛋白比例更高。这些结果表明，佝偻病时骨胶原合成增加，但它们没有提供任何关于胶原成熟缺陷的证据。2. 体外需氧培养的佝偻病骨骼比正常骨骼消耗更多葡萄糖并释放更多乳酸。预先用维生素D处理48小时的佝偻病雏鸡的骨骼糖酵解速率几乎正常。尽管我们无法在体外显示维生素D的任何直接作用，但我们认为维生素D可能对骨骼有直接作用，可能与基质生物合成有关。
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