金黄色葡萄球菌对乳糖的代谢及其遗传基础。
Metabolism of lactose by Staphylococcus aureus and its genetic basis.
作者信息
Morse M L, Hill K L, Egan J B, Hengstenberg W
出版信息
J Bacteriol. 1968 Jun;95(6):2270-4. doi: 10.1128/jb.95.6.2270-2274.1968.
Abstract
THE METABOLISM OF LACTOSE WAS FOUND TO BE CONTROLLED BY THREE GENES
a gene for the synthesis of a beta-galactosidase attacking only phosphorylated galactosides; a gene for a protein permitting concentration of phosphorylated galactosides which probably acts by transferring phosphates to them; and a gene regulating the first two structural genes. The three genes are closely linked and may have the same order as in Escherichia coli. Galactose-6-phosphate was found to be a better inducer of lactose utilization than is galactose or any other inducer. The inhibition of induction by isopropylthiogalactoside was found to occur at the level of the protein permitting the concentration of galactoside phosphates.
摘要
发现乳糖代谢受三个基因控制
一个基因负责合成仅作用于磷酸化半乳糖苷的β-半乳糖苷酶；一个基因负责合成一种蛋白质，该蛋白质可能通过将磷酸基团转移到磷酸化半乳糖苷上，从而使其得以浓缩；还有一个基因负责调控前两个结构基因。这三个基因紧密连锁，其排列顺序可能与大肠杆菌中的相同。发现6-磷酸半乳糖是比半乳糖或任何其他诱导剂更好的乳糖利用诱导剂。发现异丙基硫代半乳糖苷对诱导的抑制作用发生在允许半乳糖苷磷酸浓缩的蛋白质水平上。
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