Alexander R A, Garner A
Histopathology. 1977 May;1(3):189-99. doi: 10.1111/j.1365-2559.1977.tb01658.x.
Oxytalan is a fibrillar protein possessing some of the staining and ultrastructural properties of developing elastic tissue. In a study of human corneae we failed to find fibres of this type in five normal specimens but found them in each of 16 examples of keratoconus and 13 cases of post-traumatic or post-inflammatory scarring. In two cases the microfibrillar nature of the deposits was confirmed by electron microscopy, individual microfibrils measuring 10-12 nm in diameter and having profiles suggestive of a tubular structure. Oxytalan formation was intimately associated with the basal lamina of the covering epithelium with, in areas showing disruption of Bowman's layer and scarring, some extension into the superficial collagenous stroma.
弹力纤维原纤维是一种纤维状蛋白质，具有发育中的弹性组织的一些染色和超微结构特性。在一项对人角膜的研究中，我们在5个正常标本中未发现这种类型的纤维，但在16例圆锥角膜和13例创伤后或炎症后瘢痕形成的病例中均发现了它们。在2例中，通过电子显微镜证实了沉积物的微纤维性质，单个微纤维直径为10 - 12纳米，其轮廓提示为管状结构。弹力纤维原纤维的形成与覆盖上皮的基底膜密切相关，在显示Bowman层破坏和瘢痕形成的区域，有一些延伸至浅层胶原基质。
