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Hyperprolactinemia was found in 73 out of 445 patients as the underlying cause of primary or secondary amenorrhea, There was only in 65 cases both amenorrhea and galactorrhea. 2. Pituitary tumors were found in 21 cases. The causes of hyperprolactinemia in the other patients remained unclear. 3. Concentration of LH and FSH in serum was normal or lowered. Stimulation of LH and FSH by LHRH was possible only in part. 4. Regardless of the cause of hyperprolactinemia in all patients hPRL-levels were lowered significantly by 2.5 mg CB 154 within 4 hours. 5. Longtime suppression of hPRL by CB 154 normalized LH- and FSH- concentrations in serum and its response to LHRH. 6. Ovulatory cycles were observed in all cases treated by CB 154 (N = 25), 11 patients became pregnant.

在445例原发性或继发性闭经患者中，发现73例存在高催乳素血症，其中仅65例同时出现闭经和溢乳。2. 发现21例患有垂体肿瘤。其他患者高催乳素血症的病因仍不清楚。3. 血清中促黄体生成素（LH）和促卵泡生成素（FSH）浓度正常或降低。促性腺激素释放激素（LHRH）对LH和FSH的刺激仅部分有效。4. 无论高催乳素血症的病因如何，所有患者在4小时内给予2.5毫克甲磺酸溴隐亭（CB 154）后，人催乳素（hPRL）水平均显著降低。5. 甲磺酸溴隐亭（CB 154）对hPRL的长期抑制作用使血清中LH和FSH浓度及其对LHRH的反应恢复正常。6. 在所有接受甲磺酸溴隐亭（CB 154）治疗的病例（N = 25）中均观察到排卵周期，11例患者怀孕。

Hyperprolactinemia was found in 73 out of 445 patients as the underlying cause of primary or secondary amenorrhea, There was only in 65 cases both amenorrhea and galactorrhea. 2. Pituitary tumors were found in 21 cases. The causes of hyperprolactinemia in the other patients remained unclear. 3. Concentration of LH and FSH in serum was normal or lowered. Stimulation of LH and FSH by LHRH was possible only in part. 4. Regardless of the cause of hyperprolactinemia in all patients hPRL-levels were lowered significantly by 2.5 mg CB 154 within 4 hours. 5. Longtime suppression of hPRL by CB 154 normalized LH- and FSH- concentrations in serum and its response to LHRH. 6. Ovulatory cycles were observed in all cases treated by CB 154 (N = 25), 11 patients became pregnant.

在445例原发性或继发性闭经患者中，发现73例存在高催乳素血症，其中仅65例同时出现闭经和溢乳。2. 发现21例患有垂体肿瘤。其他患者高催乳素血症的病因仍不清楚。3. 血清中促黄体生成素（LH）和促卵泡生成素（FSH）浓度正常或降低。促性腺激素释放激素（LHRH）对LH和FSH的刺激仅部分有效。4. 无论高催乳素血症的病因如何，所有患者在4小时内给予2.5毫克甲磺酸溴隐亭（CB 154）后，人催乳素（hPRL）水平均显著降低。5. 甲磺酸溴隐亭（CB 154）对hPRL的长期抑制作用使血清中LH和FSH浓度及其对LHRH的反应恢复正常。6. 在所有接受甲磺酸溴隐亭（CB 154）治疗的病例（N = 25）中均观察到排卵周期，11例患者怀孕。

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