Guttman R, Barnhill R
J Gen Physiol. 1968 Jun;51(6):759-69. doi: 10.1085/jgp.51.6.759.
Accommodation and excitation in space-clamped squid axons were studied with the double sucrose gap technique, using linear current ramps, short (50 microsec) square wave pulses, and rheobasic square wave pulses as stimuli. The temperature was varied from 5 degrees to 35 degrees C. Experimental results showed a Q(10) for accommodation which was 44% higher than that for excitation. Yet calculations on the basis of the Hodgkin-Huxley equations predict equal Q(10)'s for excitation and accommodation. Although the Hodgkin-Huxley equations are spectacularly successful for so many nerve phenomena, the differences between calculations of accommodation and these experiments, which were designed to test the equations, show that the equations need modification in this area.
采用双蔗糖间隙技术，利用线性电流斜坡、短（50微秒）方波脉冲和基强度方波脉冲作为刺激，研究了空间钳制乌贼轴突中的适应和兴奋现象。温度在5摄氏度至35摄氏度之间变化。实验结果表明，适应的Q(10)比兴奋的Q(10)高44%。然而，基于霍奇金-赫胥黎方程的计算预测兴奋和适应的Q(10)相等。尽管霍奇金-赫胥黎方程在解释众多神经现象方面取得了惊人的成功，但旨在检验这些方程的适应计算与实验之间的差异表明，这些方程在这方面需要修正。
