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鱿鱼轴突中振荡的温度依赖性:实验与计算的比较

Temperature dependence of oscillation in squid axons: comparison of experiments with computations.

作者信息

Guttman R

出版信息

Biophys J. 1969 Mar;9(3):269-77. doi: 10.1016/S0006-3495(69)86385-X.

DOI:10.1016/S0006-3495(69)86385-X
PMID:5780709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1367567/
Abstract

The temperature dependence of the oscillatory behavior of experimental and computed axons was compared. In the experimental study of space-clamped giant axons of the squid, small oscillations after a single threshold spike were measured using the double glucose gap over the temperature range 10 degrees -30 degrees C during treatment with three concentrations of external CaCl(2) solutions. Calcium concentration had little effect on frequency, as was found also by Huxley in his computations at 18.5 degrees C for a fiber at rest. The Q(10) both for the experimental and for the computed axon of FitzHugh was 2.25. The experimental measurements of the frequency of oscillations near threshold agree extremely well with the Hodgkin-Huxley calculations.

摘要

比较了实验性和计算性轴突振荡行为的温度依赖性。在对鱿鱼空间钳制的巨轴突进行的实验研究中,在10摄氏度至30摄氏度的温度范围内,使用双葡萄糖间隙测量了在三种浓度的外部氯化钙溶液处理期间单个阈下峰后的小振荡。钙浓度对频率影响很小,赫胥黎在18.5摄氏度对静息纤维的计算中也发现了这一点。实验性和菲茨休计算性轴突的Q(10)均为2.25。阈下振荡频率的实验测量结果与霍奇金-赫胥黎的计算结果极为吻合。

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本文引用的文献

1
Multiple response to constant current in frog's medullated nerve.蛙有髓神经对恒定电流的多重反应。
J Physiol. 1936 Nov 6;88(2):239-55. doi: 10.1113/jphysiol.1936.sp003435.
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The threshold conditions for initiation of action potentials by excitable cells.可兴奋细胞产生动作电位的阈值条件。
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The local electric changes associated with repetitive action in a non-medullated axon.与无髓鞘轴突重复活动相关的局部电变化。
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Nature. 1964 Feb 8;201:625-6. doi: 10.1038/201625a0.
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Jpn J Physiol. 1958 Sep 15;8(3):234-45. doi: 10.2170/jjphysiol.8.234.
6
The action of calcium on the electrical properties of squid axons.钙对鱿鱼轴突电特性的作用。
J Physiol. 1957 Jul 11;137(2):218-44. doi: 10.1113/jphysiol.1957.sp005808.
7
Excitation and conduction in crustacean single motor axons.甲壳类单根运动轴突中的兴奋与传导
J Cell Comp Physiol. 1954 Apr;43(2):133-64. doi: 10.1002/jcp.1030430203.
8
A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
9
Digital computer solutions for excitation and propagation of the nerve impulse.用于神经冲动激发与传播的数字计算机解决方案。
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