培养的成纤维细胞中吞噬体的破坏机制。食人鱼分解作用。
A mechanism for the destruction of pinosomes in cultured fibroblasts. Piranhalysis.
作者信息
Willingham M C, Yamada S S
出版信息
J Cell Biol. 1978 Aug;78(2):480-7. doi: 10.1083/jcb.78.2.480.
Abstract
The destruction of large pinosomes was examined with phase-contrast microscopy in cultured mouse fibroblasts. In areas of rapid pinosome breakdown, lysosomes were observed to repeatedly collide with pinosomes without fusing, tearing off small pieces until the pinosomes became smaller and denser. This segmentation of pinosomes by lysosomal collision has been named "piranhalysis."
摘要
在培养的小鼠成纤维细胞中，利用相差显微镜观察了大型吞噬体的破坏情况。在吞噬体快速分解的区域，观察到溶酶体反复与吞噬体碰撞但不融合，撕下小块，直到吞噬体变得更小、更致密。溶酶体碰撞导致吞噬体的这种分割被称为“噬鲳溶解”。
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