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疱疹样皮炎患者皮肤中IgA结合结构的鉴定

Identification of IgA binding structures in skin of patients with dermatitis herpetiformis.

作者信息

Yaoita H

出版信息

J Invest Dermatol. 1978 Sep;71(3):213-6. doi: 10.1111/1523-1747.ep12547280.

DOI:10.1111/1523-1747.ep12547280
PMID:567664
Abstract

Immunoelectronmicroscopic and ultrastructural identification of the structures which bind IgA in skin of patients with dermatitis herpetiformis (DH) reveals them to be, in part, a complex of fibrillar components which are covered with amorphous substances. One of the fibers has a diameter of 80--130 A and appears to be tubular, resembling dermal microfibrillar bundles or microtubular elements of elastic fibers. The structures, at times, are associated with the dermal microfibrillar bundles and are found within an elastic fiber system which is in close proximity to the dermal-epidermal junction. Taken together, these findings suggest that the structures which bind IgA are unique to DH and might be a part of an abnormal dermal microfibrillar bundle-elastic fiber system.

摘要

对疱疹样皮炎(DH)患者皮肤中与IgA结合的结构进行免疫电子显微镜和超微结构鉴定,结果显示,其中部分结构是由纤维状成分组成的复合体,表面覆盖有无定形物质。其中一种纤维直径为80 - 130埃,呈管状,类似于真皮微纤维束或弹性纤维的微管成分。这些结构有时与真皮微纤维束相关联,并存在于紧邻真皮 - 表皮交界处的弹性纤维系统内。综合来看,这些发现表明与IgA结合的结构是DH所特有的,可能是异常真皮微纤维束 - 弹性纤维系统的一部分。

相似文献

1
Identification of IgA binding structures in skin of patients with dermatitis herpetiformis.疱疹样皮炎患者皮肤中IgA结合结构的鉴定
J Invest Dermatol. 1978 Sep;71(3):213-6. doi: 10.1111/1523-1747.ep12547280.
2
IgA-binding structures in dermatitis herpetiformis skin are independent of elastic-microfibrillar bundles.疱疹样皮炎皮肤中的IgA结合结构独立于弹性微原纤维束。
J Invest Dermatol. 1991 Jan;96(1):88-92. doi: 10.1111/1523-1747.ep12515903.
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Dermatitis herpetiformis bodies. Ultrastructural study on the skin of patients using direct preembedding immunogold labeling.疱疹样皮炎小体。对使用直接包埋前免疫金标记法的患者皮肤进行超微结构研究。
Arch Dermatol. 1990 Nov;126(11):1469-74.
4
Immunoelectron microscopic examination of IgA deposition in dermatitis herpetiformis.疱疹样皮炎中IgA沉积的免疫电子显微镜检查。
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IgA immunoreactive deposits collocal with fibrillin immunoreactive fibers in dermatitis herpetiformis skin.在疱疹样皮炎皮肤中,免疫球蛋白A免疫反应性沉积物与原纤维蛋白免疫反应性纤维共定位。
Acta Derm Venereol. 1990;70(3):194-8.
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Electron microscopic studies in dermatitis herpetiformis in relation to the pattern of immune deposits in the skin.疱疹样皮炎的电子显微镜研究与皮肤免疫沉积物模式的关系。
Arch Dermatol Res (1975). 1977 Sep 27;259(3):213-24. doi: 10.1007/BF00561449.
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Ultrastructural localization of immunoglobulins in skin of patients with dermatitis herpetiformis.疱疹样皮炎患者皮肤中免疫球蛋白的超微结构定位
J Invest Dermatol. 1976 Oct;67(4):507-12. doi: 10.1111/1523-1747.ep12664537.
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Fibrillar IgA deposition in dermatitis herpetiformis--an underreported pattern with potential clinical significance.疱疹样皮炎中的纤维状IgA沉积——一种报道不足但具有潜在临床意义的模式。
J Cutan Pathol. 2010 Apr;37(4):475-7. doi: 10.1111/j.1600-0560.2009.01472.x. Epub 2009 Nov 16.
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Immunoglobulin, complement and epidermal transglutaminase deposition in the cutaneous vessels in dermatitis herpetiformis.疱疹样皮炎皮肤血管中的免疫球蛋白、补体及表皮转谷氨酰胺酶沉积
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Immunoelectronmicroscopic localization of IgA in skin of patients with dermatitis herpetiformis.疱疹样皮炎患者皮肤中IgA的免疫电子显微镜定位
J Invest Dermatol. 1976 Oct;67(4):502-6. doi: 10.1111/1523-1747.ep12664534.

引用本文的文献

1
Recent advances in dermatitis herpetiformis.疱疹样皮炎的最新进展
Clin Dev Immunol. 2012;2012:914162. doi: 10.1155/2012/914162. Epub 2012 Jul 2.
2
Dermatitis herpetiformis.疱疹样皮炎
Springer Semin Immunopathol. 1981 Jun;4(1):33-43. doi: 10.1007/BF01891883.
3
A simple method for elution of IgA deposits from the skin of patients with dermatitis herpetiformis.一种从疱疹样皮炎患者皮肤中洗脱IgA沉积物的简单方法。
Arch Dermatol Res. 1989;281(6):406-10. doi: 10.1007/BF00455326.