• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Hypothalamic motivational systems: fixed or plastic neural circuits?

作者信息

Wise R A

出版信息

Science. 1968 Oct 18;162(3851):377-9. doi: 10.1126/science.162.3851.377.

DOI:10.1126/science.162.3851.377
PMID:5677536
Abstract

Eating and drinking were elicited by electrical stimulation through the same electrode in the hypothalamus of a satiated rat. Intensity thresholds for eliciting eating and drinking were different, and both thresholds decreased with repeated testing. These findings suggest an alternative to the hypothesis that the neural organization of hypothalamic drive systems is modified by experience.

摘要

相似文献

1
Hypothalamic motivational systems: fixed or plastic neural circuits?
Science. 1968 Oct 18;162(3851):377-9. doi: 10.1126/science.162.3851.377.
2
Modification of motivated behavior elicited by electrical stimulation of the hypothalamus.下丘脑电刺激引发的动机行为的改变。
Science. 1968 Mar 8;159(3819):1119-21. doi: 10.1126/science.159.3819.1119.
3
Lateral hypothalamic stimulation in satiated rats: the rewarding effects of self-induced drinking.对饱腹大鼠进行下丘脑外侧刺激:自我诱导饮水的奖赏效应。
Science. 1967 Sep 1;157(3792):1077-9. doi: 10.1126/science.157.3792.1077.
4
[14C]Deoxyglucose mapping of first-order projections activated by stimulation of lateral hypothalamic sites eliciting gnawing, eating, and drinking in rats.[14C]脱氧葡萄糖对大鼠下丘脑外侧部位刺激引发啃咬、进食和饮水时激活的一级投射的映射。
J Comp Neurol. 1980 Dec 1;194(3):617-38. doi: 10.1002/cne.901940309.
5
Refractory periods of neurons directly excited in stimulus-bound eating and drinking in the rat.大鼠在受刺激驱动的进食和饮水过程中直接被兴奋的神经元的不应期。
J Comp Physiol Psychol. 1973 Jan;82(1):15-22. doi: 10.1037/h0033800.
6
Attempt to classically condition eating and drinking elicited by hypothalamic stimulation in rats.
Physiol Behav. 1972 May;8(5):973-5. doi: 10.1016/0031-9384(72)90313-7.
7
Hypothalamic motivational systems: fixed or plastic neural circuits?下丘脑动机系统:固定的还是可塑性神经回路?
Science. 1969 Mar 7;163(3871):1084. doi: 10.1126/science.163.3871.1084.
8
Individual differences in effects of hypothalamic stimulation: the role of stimulation locus.
Physiol Behav. 1971 May;6(5):569-72. doi: 10.1016/0031-9384(71)90207-1.
9
Lateral hypothalamus: hoarding behavior elicited by electrical stimulation.外侧下丘脑:电刺激引发的囤积行为。
Science. 1967 Jan 20;155(3760):349-50. doi: 10.1126/science.155.3760.349.
10
Grooming in the rat as an aftereffect of lateral hypothalamic stimulation.
J Comp Physiol Psychol. 1976 Aug;90(8):790-8. doi: 10.1037/h0077249.

引用本文的文献

1
Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding.肥胖重塑了摄食的外侧下丘脑制动的活动和转录状态。
Science. 2019 Jun 28;364(6447):1271-1274. doi: 10.1126/science.aax1184.
2
Hypocretin as a Hub for Arousal and Motivation.下丘脑分泌素:觉醒与动机的核心
Front Neurol. 2018 Jun 6;9:413. doi: 10.3389/fneur.2018.00413. eCollection 2018.
3
Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior.外侧下丘脑对腹侧被盖区的控制:奖赏评估与动机行为驱动
Front Syst Neurosci. 2017 Jul 6;11:50. doi: 10.3389/fnsys.2017.00050. eCollection 2017.
4
Lateral hypothalamic circuits for feeding and reward.用于进食和奖赏的下丘脑外侧回路。
Nat Neurosci. 2016 Feb;19(2):198-205. doi: 10.1038/nn.4220.
5
The role of the lateral hypothalamus and orexin in ingestive behavior: a model for the translation of past experience and sensed deficits into motivated behaviors.外侧下丘脑和食欲素在摄食行为中的作用:将过去的经验和感知到的缺陷转化为动机行为的模型。
Front Syst Neurosci. 2014 Nov 13;8:216. doi: 10.3389/fnsys.2014.00216. eCollection 2014.
6
The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding.外侧下丘脑的抑制性回路结构控制摄食。
Science. 2013 Sep 27;341(6153):1517-21. doi: 10.1126/science.1241812.
7
Forebrain substrates of reward and motivation.奖赏与动机的前脑基质。
J Comp Neurol. 2005 Dec 5;493(1):115-21. doi: 10.1002/cne.20689.
8
Alcohol preference in the laboratory rat induced by hypothalamic stimulation.下丘脑刺激诱导实验大鼠的酒精偏好。
Psychopharmacologia. 1970;17(5):367-77. doi: 10.1007/BF00403808.
9
Feeding and drinking following stimulation of the diencephalon of the monkey with amines and other substances.用胺类及其他物质刺激猴子间脑后其进食与饮水情况。
Exp Brain Res. 1969;8(4):295-310. doi: 10.1007/BF00234377.
10
Self-stimulation: a rewarding decade.自我刺激:收获满满的十年。
J Psychiatry Neurosci. 1991 Sep;16(3):109-14.